ConspectusAntimicrobial resistance to present antibiotics represents one of many best threats to human well being and is rising at an alarming price. To additional complicate therapy of bacterial infections, many power infections are the results of bacterial biofilms which are tolerant to therapy with antibiotics due to the presence of metabolically dormant persister cell populations. Together these threats are creating an rising burden on the healthcare system, and a “preantibiotic” age is on the horizon if vital motion will not be taken by the scientific and medical communities. While the golden period of antibiotic discovery (1940s-1960s) produced a lot of the antibiotic courses in scientific use at this time, adopted by a number of many years of restricted growth, there was a resurgence in antibiotic drug discovery lately fueled by the tutorial and biotech sectors.
Historically, nice success has been achieved by growing next-generation variants of present courses of antibiotics, however there stays a dire want for the identification of novel scaffolds and/or antimicrobial targets to drive future efforts to overcome resistance and tolerance. In this regard, there was no extra priceless supply for the identification of antibiotics than pure merchandise, with 69-77% of accepted antibiotics both being such compounds or being derived from them.Our group has developed a program centered on the chemical synthesis and chemical microbiology of marine pure merchandise with uncommon buildings and promising ranges of exercise towards multidrug-resistant (MDR) bacterial pathogens.
As we’re motivated by making ready and finding out the organic results of those molecules, we aren’t initially pursuing a organic query however as an alternative are permitting the noticed phenotypes and actions to information the last word challenge path. In this Account, our latest efforts on the synoxazolidinone, lipoxazolidinone, and batzelladine pure merchandise might be mentioned and positioned within the context of the sphere’s best challenges and alternatives. Specifically, the synoxazolidinone household of 4-oxazolidinone-containing pure merchandise has led to the event of a number of chemical strategies to put together antimicrobial scaffolds and has revealed compounds with potent exercise as adjuvants to deal with bacterial biofilms. Bearing the identical 4-oxazolidinone core, the lipoxazolidinones have confirmed to be potent single-agent antibiotics.
Finally, our artificial efforts towards the batzelladines revealed analogues with exercise towards a variety of MDR pathogens, highlighted by non-natural stereochemical isomers with superior exercise and simplified artificial entry. Taken collectively, these research present a number of distinct platforms for the event of novel therapeutics that may add to our arsenal of scaffolds for preclinical growth and can present perception into the biochemical processes and pathways that may be focused by small molecules within the battle towards antimicrobial-resistant and -tolerant infections. We hope that this work will serve as inspiration for elevated efforts by the scientific neighborhood to leverage artificial chemistry and chemical microbiology towards novel antibiotics that may fight the rising disaster of MDR and tolerant bacterial infections.
Life sciences mental property licensing on the Massachusetts Institute of Technology
Academic establishments play a central position within the biotech trade by means of know-how licensing and the creation of startups, however few information can be found on their efficiency and the magnitude of their affect. Here we current a systematic research of know-how licensing by one such establishment, the Massachusetts Institute of Technology (MIT). Using information on the 76 therapeutics-focused life sciences corporations shaped by means of MIT’s Technology Licensing Office from 1983 to 2017, we assemble a number of measures of affect, together with MIT patents cited within the Orange Book
capital raised, outcomes from mergers and acquisitions, patents granted to MIT mental property licensees, drug candidates found and US drug approvals-a key benchmark of innovation within the biopharmaceutical trade. As of December 2017, Orange Book listings for 4 accepted small-molecule medicine cite MIT patents, however one other 31 FDA-approved medicine (excluding candidates acquired after section 3) had some involvement of MIT licensees. Fifty-five % of the latter had been both a new molecular entity or a new organic entity, and 55% had been granted precedence evaluate, a sign that they handle an unmet medical want.
Recent Advances within the Evaluation of Serological Assays for the Diagnosis of SARS-CoV-2 Infection and COVID-19
Few information on the diagnostic efficiency of serological exams for extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) an infection are presently out there. We evaluated sensitivity and specificity of 5 completely different extensively used industrial serological assays for the detection of SARS-CoV-2-specific IgG, IgM, and IgA antibodies utilizing reverse transcriptase-PCR assay in nasopharyngeal swab as reference customary take a look at. The methodology described right here could also be a helpful framework for different educational establishments to monitor outcomes of mental property within the therapeutics area
A complete of 337 plasma samples collected within the interval April-June 2020 from SARS-CoV-2 RT-PCR optimistic (n = 207) and destructive (n = 130) topics had been investigated by one point-of-care lateral stream immunochromatographic assay (LFIA IgG and IgM, Technogenetics) and 4 totally automated assays: two chemiluminescence immunoassays (CLIA-iFlash IgG and IgM, Shenzhen YHLO Biotech and CLIA-LIAISON XL IgG, DiaSorin), one electrochemiluminescence immunoassay (ECLIA-Elecsys® whole predominant IgG, Roche), and one enzyme-linked immunosorbent assay (ELISA IgA, Euroimmune.
 Mouse IgG2a Isotype Control |
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abx139009-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
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Mouse IgG2a Isotype Control |
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10R-I117d |
Fitzgerald |
1 mg |
EUR 484 |
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Description: Purified Mouse IgG2a Isotype Control |
Mouse IgG2a Isotype Control |
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abx200572-100ug |
Abbexa |
100 ug |
EUR 376.8 |
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Mouse IgG2a Isotype Control |
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abx405013-100tests |
Abbexa |
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EUR 493.2 |
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Mouse IgG2a Isotype Control |
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abx405015-05mg |
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0.5 mg |
EUR 828 |
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Mouse IgG2a Isotype Control |
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abx405018-1mg |
Abbexa |
1 mg |
EUR 1328.4 |
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Mouse IgG2a Isotype Control |
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abx405070-100tests |
Abbexa |
100 tests |
EUR 493.2 |
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Mouse IgG2a Isotype Control |
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abx405073-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
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Mouse IgG2a Isotype Control |
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E2790004 |
EnoGene |
100ul |
EUR 225 |
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Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control |
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GWB-21CA6B |
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Mouse IgG2a Isotype Control |
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GWB-233A6A |
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Mouse IgG2a Isotype Control |
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GWB-260585 |
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Mouse IgG2a Isotype Control |
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GWB-148AA9 |
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Mouse IgG2a Isotype Control |
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GWB-1C9451 |
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Mouse IgG2a Isotype Control |
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ICIGG2AA-50 |
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EUR 231 |
Mouse IgG2a Isotype Control |
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ICIGG2AF-100 |
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EUR 126.5 |
Mouse IgG2a Isotype Control |
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ICIGG2APE-50 |
ImmunoStep |
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EUR 231 |
Mouse IgG2a Isotype Control |
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ICIGG2APP-100 |
ImmunoStep |
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EUR 253 |
Mouse IgG2a Isotype Control |
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ICIGG2APP5.5-100 |
ImmunoStep |
100 µg |
EUR 253 |
Mouse IgG2a Isotype Control |
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ICIGG2APU-100 |
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EUR 126.5 |
Mouse IgG2a Isotype Control |
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GWB-957238 |
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GWB-A0AD5F |
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GWB-AEF91A |
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Mouse IgG2a Isotype Control |
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GWB-727CA0 |
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Mouse IgG2a Isotype Control |
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GWB-7829DA |
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1 mg |
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Mouse IgG2a Isotype Control |
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GWB-FA4739 |
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Mouse IgG2a Isotype Control |
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GWB-B53172 |
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GWB-C47D63 |
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Mouse IgG2a Isotype Control |
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abx139004-100l |
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EUR 250 |
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Mouse IgG2a Isotype Control |
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abx139005-100l |
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abx139009-100l |
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abx405013-250g |
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250 µg |
EUR 300 |
Mouse IgG2a Isotype Control |
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abx405018-100g |
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100 µg |
EUR 975 |
Mouse IgG2a Isotype Control |
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abx405070-100g |
Abbexa |
100 µg |
EUR 300 |
Mouse IgG2a Isotype Control |
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abx405073-250g |
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EUR 712.5 |
Mouse IgG2a Isotype Control |
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MBS655548-005mg |
MyBiosource |
0.05mg |
EUR 475 |
Mouse IgG2a Isotype Control |
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MBS655548-5x005mg |
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EUR 1990 |
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MBS8559155-01mL |
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MBS8559155-01mLAF405L |
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EUR 565 |
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MBS8559155-01mLAF405S |
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EUR 565 |
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MBS8559155-01mLAF610 |
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0.1mL(AF610) |
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MBS8559155-01mLAF635 |
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Mouse IgG2a Isotype Control |
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MBS136147-1mg |
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EUR 465 |
Mouse IgG2a Isotype Control |
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EUR 1540 |
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EUR 6695 |
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EUR 1550 |
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EUR 690 |
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MBS531354-5x1mg |
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abx139015-01mg |
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 Mouse IgG2a Isotype Control PE |
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1P-724-C025 |
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EUR 99 |
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1P-724-C100 |
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EUR 198 |
Mouse IgG2a Isotype Control (PE) |
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abx200574-50ug |
Abbexa |
50 ug |
EUR 510 |
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 PE mouse IgG2a Isotype Control |
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E16FMCP002-050 |
EnoGene |
50 tests |
EUR 235.2 |
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Description: Available in various conjugation types. |
PE mouse IgG2a Isotype Control |
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E16FMCP002-100 |
EnoGene |
100 Tests |
EUR 336 |
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Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (PE) |
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E2790239 |
EnoGene |
100ul |
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Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (PE) |
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abx159557-100g |
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100 µg |
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Mouse IgG2a Isotype Control (PE) |
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abx159557-10g |
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10 µg |
EUR 325 |
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abx139015-100l |
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abx139015-500l |
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abx405017-100g |
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EUR 512.5 |
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abx405075-100g |
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abx405075-250g |
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abx405075-25g |
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EUR 362.5 |
Mouse IgG2a Isotype Control PE |
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MBS697144-01mg |
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0.1mg |
EUR 225 |
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MBS697144-5x01mg |
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EUR 965 |
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MBS8576112-01mL |
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EUR 305 |
Mouse IgG2a Isotype Control (PE) |
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MBS8576112-01mLAF405L |
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0.1mL(AF405L) |
EUR 565 |
Mouse IgG2a Isotype Control (PE) |
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MBS8576112-01mLAF405S |
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0.1mL(AF405S) |
EUR 565 |
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MBS8576112-01mLAF610 |
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0.1mL(AF610) |
EUR 565 |
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MBS8576112-01mLAF635 |
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0.1mL(AF635) |
EUR 565 |
Mouse IgG2a Isotype Control PE |
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MBS1801354-01mg |
MyBiosource |
0.1mg |
EUR 305 |
Mouse IgG2a Isotype Control PE |
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MBS1801354-5x01mg |
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5x0.1mg |
EUR 1120 |
Mouse IgG2a Isotype Control (PE) |
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MBS4753794-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Mouse IgG2a Isotype Control (PE) |
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MBS4753794-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
) Mouse IgG2a Isotype Control (APC) |
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abx139012-01mg |
Abbexa |
0.1 mg |
EUR 510 |
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 Mouse IgG2a Isotype Control APC |
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1A-724-C025 |
ExBio |
0.025 mg |
EUR 99 |
Mouse IgG2a Isotype Control APC |
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1A-724-C100 |
ExBio |
0.1 mg |
EUR 198 |
Mouse IgG2a Isotype Control (APC) |
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abx200575-50ug |
Abbexa |
50 ug |
EUR 510 |
|
|
) Mouse IgG2a Isotype Control (RPE) |
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abx405017-100tests |
Abbexa |
100 tests |
EUR 760.8 |
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Mouse IgG2a Isotype Control (APC) |
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abx405071-100tests |
Abbexa |
100 tests |
EUR 510 |
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Mouse IgG2a Isotype Control (RPE) |
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abx405075-100tests |
Abbexa |
100 tests |
EUR 560.4 |
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 APC mouse IgG2a Isotype Control |
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E16FMCA002-050 |
EnoGene |
50 tests |
EUR 268.8 |
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Description: Available in various conjugation types. |
APC mouse IgG2a Isotype Control |
|
E16FMCA002-100 |
EnoGene |
100 Tests |
EUR 403.2 |
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Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (APC) |
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E2790222 |
EnoGene |
100ul |
EUR 225 |
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Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (APC) |
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abx139012-100l |
Abbexa |
100 µl |
EUR 350 |
Mouse IgG2a Isotype Control (APC) |
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abx139012-500l |
Abbexa |
500 µl |
Ask for price |
Mouse IgG2a Isotype Control (APC) |
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abx405071-100g |
Abbexa |
100 µg |
EUR 325 |
Mouse IgG2a Isotype Control APC |
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MBS697147-01mg |
MyBiosource |
0.1mg |
EUR 235 |
Mouse IgG2a Isotype Control APC |
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MBS697147-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1025 |
Mouse IgG2a Isotype Control (APC) |
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MBS8576095-01mL |
MyBiosource |
0.1mL |
EUR 305 |
Mouse IgG2a Isotype Control (APC) |
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MBS8576095-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Mouse IgG2a Isotype Control (APC) |
|
MBS8576095-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Mouse IgG2a Isotype Control (APC) |
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MBS8576095-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Mouse IgG2a Isotype Control (APC) |
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MBS8576095-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
 Mouse IgG2a Isotype Control, APC |
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MBS8500905-100Tests |
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EUR 305 |
Mouse IgG2a Isotype Control, APC |
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MBS8500905-50Tests |
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50Tests |
EUR 235 |
Mouse IgG2a Isotype Control, APC |
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MBS8500905-5x100Tests |
MyBiosource |
5x100Tests |
EUR 1220 |
Mouse IgG2a Isotype Control APC |
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MBS1801351-01mg |
MyBiosource |
0.1mg |
EUR 305 |
Mouse IgG2a Isotype Control APC |
|
MBS1801351-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1120 |
Mouse IgG2a Isotype Control (APC) |
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MBS4753778-01mL |
MyBiosource |
0.1mL |
EUR 450 |
Mouse IgG2a Isotype Control (APC) |
|
MBS4753778-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1540 |
APC mouse IgG2a Isotype Control |
|
MBS9459473-100Tests |
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100Tests |
EUR 290 |
APC mouse IgG2a Isotype Control |
|
MBS9459473-50Tests |
MyBiosource |
50Tests |
EUR 230 |
APC mouse IgG2a Isotype Control |
|
MBS9459473-5x100Tests |
MyBiosource |
5x100Tests |
EUR 1160 |
) Mouse IgG2a Isotype Control (FITC) |
|
abx139014-01mg |
Abbexa |
0.1 mg |
EUR 460.8 |
|
|
 Mouse IgG2a Isotype Control FITC |
|
1F-724-C025 |
ExBio |
0.025 mg |
EUR 82.5 |
Mouse IgG2a Isotype Control FITC |
|
1F-724-C100 |
ExBio |
0.1 mg |
EUR 165 |
Mouse IgG2a Isotype Control (FITC) |
|
abx200573-100ug |
Abbexa |
100 ug |
EUR 376.8 |
|
|
Mouse IgG2a Isotype Control (FITC) |
|
abx405016-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
|
Mouse IgG2a Isotype Control (FITC) |
|
abx405074-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
|
 FITC mouse IgG2a Isotype Control |
|
E16FMCF002-050 |
EnoGene |
50 tests |
EUR 168 |
|
Description: Available in various conjugation types. |
FITC mouse IgG2a Isotype Control |
|
E16FMCF002-100 |
EnoGene |
100 Tests |
EUR 268.8 |
|
Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (FITC) |
|
E2790235 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (FITC) |
|
abx159556-100g |
Abbexa |
100 µg |
Ask for price |
Mouse IgG2a Isotype Control (FITC) |
|
abx159556-10g |
Abbexa |
10 µg |
EUR 325 |
The general sensitivity of all IgG serological assays was >80% and the specificity was >97%. The sensitivity of IgG assays was decrease inside 2 weeks from the onset of signs starting from 70.8 to 80%. The LFIA and CLIA-iFlash IgM confirmed an general low sensitivity of 47.6 and 54.6%, whereas the specificity was 98.5 and 96.2%, respectively. The ELISA IgA yielded a sensitivity of 84.3% and specificity of 81.7%. However, the ELISA IgA consequence was indeterminate in 11.7% of circumstances.
