First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial.

First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial.

BACKGROUNDBisphosphonates scale back the danger of skeletal occasions in sufferers with malignant bone illness, and zoledronic acid has proven potential anticancer results in preclinical and medical research. We aimed to ascertain whether or not bisphosphonates can have an effect on medical outcomes in sufferers with multiple myeloma.METHODSPatients of age 18 years or older with newly … Read more

The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs.

The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs.

Despite a number of modern medicines gaining worldwide approval in current years, there are nonetheless therapeutic areas for which unhappy therapeutic wants persist. For instance, excessive unmet scientific want was noticed in sufferers identified with kind 2 diabetes mellitus and hemophilia, in addition to in particular age teams, comparable to the pediatric inhabitants. Given the … Read more

What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Liposomes are thought of one of the profitable drug supply techniques (DDS) given their established utility and success within the clinic. In the previous 40⁻50 years, Canadian scientists have made ground-breaking discoveries, lots of which have been efficiently translated to the clinic, resulting in the formation of biotech corporations, the creation of analysis instruments, such because the Lipex Extruder … Read more