COVID-19 Ag Home Test

Why test for COVID-19 at home?

  • To determine if you need to self-isolate.
  • To protect others from infection by COVID-19.
  • To support decisions about your care.

When to use it?

  • If you want to diagnose a current COVID-19 infection.
  • If you are concerned that you have been infected with COVID-19.

Description

Home test STANDARD Q COVID-19 Ag

Nose swab

  • Insert the swab about 1.5 cm into the nostril.
  • Less invasive and technically less complex than a sampling of other upper airway sites.

Reliable test performance

82.5% sensitivity and 99.9% specificity when tested by patients in Germany*

Fast test time

Getting a quick result in 15 minutes.

Simple test method

The STANDARD Q COVID-19 Ag Home test does not require a qualified professional or equipment to interpret the test results.

What is the rapid antigen test?

Rapid antigen tests could help quickly identify those who may have been exposed to the virus and isolate them from the community. STANDARD Q COVID-19 Ag Home Test is a rapid antigen test to detect infection in people suspected of having COVID-19.

How can this diagnose COVID-19 in just 15 minutes?

This test detects the presence of viral proteins called the COVID-19 virus antigen. If an antigen is present in the respiratory sample, the test device will capture it and display it to you through a coloured band. With technology from global diagnostic company SD Biosensor, you can get highly accurate results within 15 minutes.

This is a safe test for the detection of COVID-19 infection. This test is ideally designed to protect you and your family from the spread of the virus. During the test, you will place a swab soaked in the sample into the “solution tube.” This solution works to perform tests, while at the same time inactivating the virus. This avoids the risk of infection by inactivating the virus in 2 minutes without affecting the test results.

DU-50 Genomic DNA Extraction Kit cells, tissues, blood

Process any sample at any scale

Our wide range of genomic DNA extraction kits are grouped here by sample type, so you can easily find the best DNA extraction kit for your needs. Regardless of sample type, you can expect high yields and high-quality DNA to use in your downstream applications.

Our products cover a variety of performance options and processing methods, giving you flexible options. If you want to run fewer than 24 samples at a time, choose from our manual single-prep solutions. If you’re looking for an automated solution, our cartridge-based kits for use with Maxwell® Instruments can process up to 48 samples in the same run. We also offer kits designed for fully automated plate-based processing methods.

DNA Purification Kits

Classic DNA Purification Kits use a silica resin to tightly bind DNA under high-salt conditions, allowing proteins, small RNAs, and other molecules to be removed by washing steps with a salt/ethanol solution. After washing, the purified DNA is eluted in water or TE buffer. A broad portfolio of GenElute™ DNA purification kits tailored to specific sample types is available, enabling purification of genomic DNA (gDNA) from cell culture, mammalian tissue, blood, bacteria, viruses, plant tissue, soil, water, urine and faeces.

GenElute™ Cell-Free DNA Kits provide rapid and efficient purification of circulating free DNA (cfDNA) to recover cell-free DNA fragments in the 100 bp to 500 bp range, suitable for a wide range of downstream applications, including next-generation sequencing, qPCR and bisulfite sequencing.

Characteristics:

  • Silica-based DNA purification method
  • High-purity, high-yield DNA at the lowest cost per preparation
  • Most common technique used for DNA purification in laboratory workflows
  • ~90 min protocol (varies based on lysis time)
  • The complete portfolio of kits tailored to specific sample types
  • Vacuum and spin formats
  • Multi-analyte (RNA/DNA dual co-purification kits) available

Evaluation of DNA extraction

  • Spectrophotometer and Qubit Measurements.

The purity of the DNA extracted with each method was evaluated using an Eppendorf photometer. The absorbance ratio at 260 nm and 280 nm was used to assess protein contamination, while the absorbance ratio at 260 nm and 230 nm was calculated to assess guanidine contamination. Both spectrophotometric measurements constituted criteria for the evaluation of DNA quality with higher values ​​associated with better DNA purity. The amount of DNA extracted by the different methods was evaluated using the Qubit 2.0 fluorometer (Invitrogen, Life technologies).

The Qubit fluorometer calculates the concentration based on the fluorescence of a dye that binds to double-stranded DNA (dsDNA). The Qubit fluorometer captures this fluorescence signal and converts it to a measure of DNA concentration using DNA standards of known concentration. The Qubit dsDNA BR assay kit was used for DNA quantification. Based on the DNA concentration derived from the Qubit measurements and the volume of the DNA extract, the total DNA yield was calculated with a simple multiplication.

  • Gel electrophoresis.

The integrity of the DNA extracted by each method was assessed by gel electrophoresis. Specifically, 1 μl of each DNA extract was analyzed on a 1.5% agarose gel containing 0.5% ethidium bromide and visualized by U.V. illumination.

  • Real-time PCR.

Real-time PCR targeting the ovine prion protein (PRNP) gene was used to assess the presence of amplifiable DNA in blood sample extracts. The set of primers (which amplify a 168 bp PRNP genomic region), amplification reaction setup and thermocycling conditions described in a previous study were also applied here. Ct values ​​were used to assess the amount of amplifiable DNA obtained. In this regard, smaller Ct values ​​are desirable.

A second real-time PCR protocol was applied to assess the ability of different genomic DNA extraction protocols to remove PCR inhibitors from blood samples. The presence of PCR inhibitors in genomic DNA extracts was tested by adding 1000 bacterial genomic copies of DNA (Campylobacter coli C. coli, strain ATCC 43478) to 100 ng and 1000 ng sheep DNA extracts, respectively, followed by real-time PCR amplification. of the hydroxymethyltransferase (GLA) gene. Real-time PCR amplifications were performed with a Biorad CFX96 real-time system.

All samples were tested in triplicate, while three controls containing only the C. coli DNA tip (no sheep DNA) were included in each PCR test. The Ct values ​​obtained in the process were used to evaluate the presence of PCR inhibitors. Specifically, the resulting inhibition of amplification was evaluated in comparison to the unenriched control.

Casein Peptone

Casein peptones are manufactured by enzymatic hydrolysis of selected milk proteins. Traditionally used enzyme preparations have long been based on natural active ingredients such as pancreatin. Biotechnological enzymes obtained by fermentation are increasingly used today. To avoid any BSE contamination, Organotechnie exclusively uses milk proteins produced in non-affected countries such as New Zealand. In addition, the casein we use comes from milk intended for human consumption and meets the requirements of regulatory agencies.

Definition

Casein Peptone Plus is a multipurpose pancreatic casein hydrolyzate enriched with growth factors

Description

  • The fine cream powder is easily soluble in water.
  • Contains a blend of peptides, free amino acids and growth factors.
  • Casein Peptone Plus is made only from New Zealand milk material.

Use

Source of organic nitrogen and growth factors recommended in media for:

Analytical Microbiology
Industrial fermentation (pharmaceutical, food, cosmetic)
Life sciences

Documentation

A certificate of analysis and a health certificate is delivered with each delivery.

Packaging and storage

  • 25 kg net corrugated cardboard box with inner polyethene bags.
  • On request: 5 kg plastic drum.
  • Store in its original closed packaging when not in use.
  • at room temperature in a dry place.
  • Hygroscopic product.
  • Shelf life: 5 years.

SARS-CoV-2 Variant Detection Test

What’s new in this update?

  • The reference list of available assays has been updated.
  • Delta and Omicron variant assays have been included.
  • The Rapid Antigen Detection Tests chapter has been updated to include information related to the Health Security Committee’s list of mutually recognized tests in EU/EEA countries.

Key messages

  • Several SARS-CoV-2 VOCs have emerged in recent months and monitoring their circulation in all countries is of vital importance to prevent and control the spread of VOCs.
  • Complete sequencing of the SARS-CoV-2 genome, or at least complete or partial sequencing of the S gene, should be used to confirm infection with a specific variant and to characterize the variant.
  • For early detection and estimation of VOC prevalence (or where sequencing capacity is limited), alternative methods such as NAAT-based diagnostic tests should be used. To contain or delay the introduction of a VOC, ideally, positive samples should be tested using a NAAT-based assay that can offer the advantage of rapid results.
  • When NAAT-based methods are employed, sequencing should be used to characterize at least a subset of the variants.
  • In case of the low prevalence of a VOC in the population and when the goal is to delay the introduction and spread of the VOC, ideally, all NAAT-based results indicative of the VOC should be confirmed by sequencing.
  • The selection of samples and methods is key and will depend on the objectives (eg, evaluating the circulation of the different variants of SARS-CoV-2 using representative samples of the community, or genomic characterization to monitor the evolution of the virus and inform decisions about vaccine composition or outbreak analyses).
  • Assay validation should be performed to ensure that the laboratory testing system is working properly for circulating viruses.
  • Laboratories must remain vigilant to ensure that they detect reduced sensitivity or failure to detect/identify circulating variants by different PCR or antigen-based assays.
  • If diagnostic capacity is insufficient, priority should be given to severe cases, fatal cases, and cases with suspected high contagiousness of the pathogen that caused the outbreak, especially among those vaccinated or with a history of COVID-19.
  • SARS-CoV-2 consensus sequences should be submitted to GISAID or other public databases. Raw sequences should also be submitted to the European Nucleotide Archive (ENA).
  • Detection of new VOCs or outbreaks of currently circulating VOCs must be reported immediately through the Early Warning and Response System (EWRS), while variant detections must be reported to Tessy on a weekly basis.

SARS-CoV-2 variants with CDC classification

1. Lineage (VOC).

Originally from the UK, The B.1.1.7 variant contains many genetic mutations. the variant was first identified in September 2020. Since then, the variant it can been found in numerous countries around the world. The tension was found in the United States in late December 2020. It has become the most common strain in the US and is associated with higher transmissibility (i.e., more efficient with rapid transmission) and increased mortality.

2. Lineage B.1.351 (VOC).

In South Africa, the variant B.1.351 arose independently of B.1.1.7, although the variant shares some genetic mutations with the strain. B.1.351 was the first identified in South Africa in samples dating from early October 2020. Since then, cases have been detected in several countries, including the US in 2021.

3. Lineage P.1 (VOC).

The P.1 variant was first identified in Brazil Travellers. The variant has 17 unique genetic mutations, including three in the receptor-binding domain (RBD) region of the spike protein. Surveillance detected the variant in the US in late January 2021. Variant P.1 represents a branch of the B.1.1.28 lineage. Evidence suggests that some of the mutations in the P.1 variant may affect transmissibility and antigenic profile. The appearance of the variant and the association with higher viral density raised concerns about possible increased transmission or a propensity for reinfection.

4. B.1.427 and B.1.429 (VOC).

Both strains of coronavirus California are now officially characterized. Deformations can be 20% more transmissible than the common strains found in California, Nevada, Arizona, Wisconsin and Virginia.

5. B.1.526 (VOI).

First detected in New York in November 2020, the B.1.526 is a variant of interest. For February 2021 mutations appeared in about 25% of the entire COVID genomes.

HRP Dilution Buffer

Thermo Scientific Pierce Poly-HRP Dilution Buffer is optimized to ensure optimal performance with Poly-HRP Streptavidin.

Characteristics of Poly-HRP Dilution Buffer:

  • Formulation: 1% biotin-free casein in a PBS buffer solution.
  • Application: Dilution of Poly-HRP Streptavidin (Product # N200): Gently invert bottle and shake to mix before use.

do not shake Use it at full strength. See the Streptavidin Poly-HRP Certificate of Analysis for recommended dilution ranges. Dilute Poly-HRP Streptavidin immediately before use.

Related products: Streptavidin poly-HRP

Specifications

Reagent type: Diluent

Format: Liquid

Content and storage

Shipped in cold packs. Store at 2°C to 8°C immediately upon receipt.

Diluent for long-term storage of HRP conjugates

Improved formulation to improve stability and activity

  • HRP-Protector™ is a long-term stabilizer for horseradish peroxidase (HRP) coupled to antibodies or neutravidin/streptavidin. HRP-Protector™ gives peroxidase conjugates crucial long-term stability for several years, even when stored at low concentration dilutions. HRP-Protector™ can be used directly as assay buffer to incubate HRP conjugates.
  • Typical concentrations for detection are between 40 and 500 ng/mL.
  • If you have any background or interference, eg from cross-reactivities, we recommend that you use LowCross® HRP-Stab as a long-term stabilizer for the conjugate.
  • The old formulation is still available.
  • Order number 220 050 (50 mL), order number 220 125 (125 mL), and order number 220 500 (500 mL).

In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?

In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?
In vivo genome enhancing instruments, similar to these primarily based on CRISPR, have been more and more utilized in each primary and translational neuroscience analysis. There are at the moment 9 in vivo non-CNS genome enhancing therapies in medical trials, and the pre-clinical pipeline of main biotechnology firms show that this quantity will proceed to develop. Several biotechnology firms commercializing in vivo genome enhancing and modification applied sciences are growing therapies for CNS problems with accompanying giant partnering offers. In this assessment, the authors focus on the present genome enhancing and modification remedy pipeline and people in improvement to deal with CNS problems.
The coronavirus illness 2019 (COVID-19) pandemic is extreme and has not proven any indicators of warning as much as right this moment. Biotech firms round the world have raced to give you an appropriate vaccine and lately two mRNA vaccines have acquired emergency utilization authorisation from regulatory our bodies in a number of nations. mRNA vaccines, which encompass a brand new and revolutionary expertise haven’t been beforehand examined extensively on people. The NG-Test CARBA 5 package appropriately recognized 43 samples (89.5%). The sensitivity and specificity of the kits had been 86.8% and 100%, respectively.
Medium- and long-term security information are usually not accessible. While many specialists appear to assist the begin of a mass vaccination marketing campaign, others really feel there are too many unknowns to embark on a mass vaccination marketing campaign. Concerns embrace uncertainties about the long-term results of overseas mRNA on human mobile physiology and the risk of vaccine-enhanced illness severity, which is probably not unlikely with the present illness presentation of COVID-19. The authors additionally focus on the technical and industrial limitations to translation of those identical therapies and potential avenues to beat these hurdles.

Detection of Carbapenem-Resistant Enterobacterales in Simulated Blood Culture in 15 Minutes

Bacteremia resulting in sepsis and organ dysfunction is a life-threatening scenario, resulting in demise of as much as one fourth of the contaminated people round the world. One main problem in the therapy of sepsis is the rising prevalence of antibiotic resistant micro organism, similar to carbapenem-resistant Enterobacterales (CRE). In current years, a number of molecular assays have been developed for the detection of CRE mechanisms, enabling fast outcomes reporting. We evaluated the efficiency of the NG-Test CARBA 5 (NG Biotech) package in detection of CRE in simulated blood cultures.

Carbapenemase-producing (CP) CRE isolates (n = 38) and non-carbapenemase CRE (Non-CP) isolates (n = 10), beforehand recognized utilizing the routine strategies practiced at the medical microbiology laboratory of the Baruch Padeh Medical Center, Israel, had been used in this evaluation. Variable concentrations of the bacterial isolates had been added to a suspension composed of human blood and saline, simulating the composition of a blood tradition. Samples had been then transferred to an anaerobic blood tradition bottle and later examined with the NG-Test CARBA 5 (NG Biotech) package, that identifies the CRE mechanism inside 15 min.  In conclusion, the NG-Test CARBA 5 package is a dependable and accessible instrument for the fast analysis of CRE bloodstream infections.

In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?

[In vitro assay of biological activity of a national preparation of macrophage activating factor (GcMAF-RF)]

The article reviews an authentic technique for producing vitamin D3-binding protein (DBP) and its conversion into macrophage-activating issue GcMAF-RF. According to an authentic protocol, DBPs had been obtained from human blood plasma utilizing affinity chromatography, purified and modified to GcMAF-RF utilizing cytoimmobilized glycosidases (beta-galactosidase and neuraminidase). The presence of the polypeptide obtained in the Gc group of blood plasma globulins was confirmed by Western blot utilizing particular antibodies. The molecular properties of this polypeptide put it in correspondence with the GcMAF protein described in the literature, which is present process medical trials in the USA, Britain, Israel and Japan (at Saisei Mirai; Reno Integrative Medical Center; Immuno Biotech Ltd; Efranat; and Catalytic Longevity).

The organic exercise of the GcMAF-RF preparation was detected by the induction of phagocytic exercise of macrophages and their skill to provide nitrogen monoxide (NO) in vitro. The phagocytic exercise of macrophages was evaluated by their skill to uptake magnetic beads. The diploma of activation of macrophages was calculated by the ratio of trapped beads to the complete variety of macrophages. The degree of NO manufacturing was estimated by the accumulation of nitrogen monoxide in the tradition supernatants of peritoneal macrophages by the colorimetric technique utilizing the Griess reagent. It was proven that GcMAF-RF multiplies the phagocytic exercise of macrophages and considerably will increase their manufacturing of nitrogen monoxide.

Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B 100 ug
EUR 164
Rat IgG-FITC conjugate (isotype control) (Isotype control)
20005-F 100 ug
EUR 164
Rat IgG-HRP conjugate (isotype control) (Isotype control)
20005-HP 100 ug
EUR 164
Rat IgG-PE conjugate (isotype control) (Isotype control)
20005-PE 25 tests
EUR 202
Rat IgG Isotype Control
31-AR15 10 mg
EUR 220
Description: Purified Rat IgG Isotype Control
IgG Isotype Control antibody
10R-6524 50 ug
EUR 133
Description: Armenian Hamster monoclonal IgG Isotype Control antibody
IgG Isotype Control antibody
10R-6525 50 ug
EUR 133
Description: Syrian Hamster monoclonal IgG Isotype Control antibody
Rabbit IgG Isotype Control
abx125003-100ul 100 ul
EUR 203
  • Shipped within 5-10 working days.
Rabbit IgG Isotype Control
IC001-100ul 100ul
EUR 122
Mouse IgG Isotype Control
IC002-100ul 100ul
EUR 122
Goat IgG (fc)-Biotin conjugate (isotype control)
20011-Fc-B 100 ug
EUR 164
Goat IgG (fc)-FITC conjugate (isotype control)
20011-Fc-F 100 ug
EUR 164
Goat IgG (fc)-HRP conjugate (isotype control)
20011-Fc-HP 100 ug
EUR 164
Goat F(ab')2 IgG Isotype Control
abx405076-05mg 0.5 mg
EUR 411
  • Shipped within 1 week.
Goat IgG (-ve control for flow cytometry) (isotype control)
20011-100 100 test
EUR 103
Rat IgG purified (isotype control)
20005-1-200 0.5 ml
EUR 103
Rat IgG, purified (Isotype control)
20005-5 5 mg
EUR 286
Sheep IgG, purified (isotype control)
20006-1 1 mg
EUR 141
Rabbit IgG-biotinylated (isotype control)
20009-BT-1 1 mg
EUR 286
IgG Isotype Control antibody (FITC)
61R-1136 50 ug
EUR 165
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (FITC)
IgG Isotype Control antibody (PE)
61R-1337 200 ug
EUR 440
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (PE)
IgG Isotype Control antibody (PE)
61R-1338 50 ug
EUR 181
Description: Syrian Hamster monoclonal IgG Isotype Control antibody (PE)
IgG Isotype Control antibody (biotin)
61R-1586 50 ug
EUR 165
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (biotin)
IgG Isotype Control antibody (biotin)
61R-1587 50 ug
EUR 165
Description: Syrian Hamster monoclonal IgG Isotype Control antibody (biotin)
IgG Isotype Control antibody (allophycocyanin)
61R-1768 100 ug
EUR 349
Description: Armenian Hamster monoclonal IgG Isotype Control antibody (allophycocyanin)
IgG Isotype Control antibody (allophycocyanin)
61R-1769 50 ug
EUR 219
Description: Syrian Hamster monoclonal IgG Isotype Control antibody (allophycocyanin)
IgG Isotype Control antibody (FITC)
61R-1800 25 ug
EUR 205
Description: Rabbit polyclonal IgG Isotype Control antibody (FITC)
FITC Rabbit IgG - Isotype control
DB-1000 100 tests
EUR 422
FITC Rabbit IgG - Isotype control
DB1000 100 tests
EUR 422
Hamster (Armenian) IgG Isotype Control
abx405028-025mg 0.25 mg
EUR 384
  • Shipped within 1 week.
Hamster (Arnenian) IgG Isotype Control
abx405029-05mg 0.5 mg
EUR 592
  • Shipped within 1 week.
Hamster (Syrian) IgG Isotype Control
abx405032-025mg 0.25 mg
EUR 384
  • Shipped within 1 week.
Armenian Hamster IgG Isotype control
AIGGA-100 100 µg
EUR 574.16
Armenian Hamster IgG Isotype control
AIGGA-25 25 µg
EUR 282.96
Armenian Hamster IgG Isotype control
AIGGB-200 200 µg
EUR 472.24
Armenian Hamster IgG Isotype control
AIGGB-50 50 µg
EUR 239.28
Armenian Hamster IgG Isotype control
AIGGF-200 200 µg
EUR 545.04
Armenian Hamster IgG Isotype control
AIGGF-50 50 µg
EUR 268.4
Armenian Hamster IgG Isotype control
AIGGPE-100 100 µg
EUR 515.92
Armenian Hamster IgG Isotype control
AIGGPE-25 25 µg
EUR 253.84
Armenian Hamster IgG Isotype control
AIGGPP-100 100 µg
EUR 574.16
Armenian Hamster IgG Isotype control
AIGGPP-25 25 µg
EUR 268.4
Armenian Hamster IgG Isotype control
AIGGPP5.5-100 100 µg
EUR 646.96
Armenian Hamster IgG Isotype control
AIGGPP5.5-25 25 µg
EUR 282.96
Armenian Hamster IgG Isotype control
AIGGPU-50 50 µg
EUR 195.6
Armenian Hamster IgG Isotype control
AIGGPU-500 500 µg
EUR 428.56
Rabbit IgG Isotype control, Concentrate
NG910C 0.5 ml
EUR 392
Syrian Hamster IgG Isotype Control
SIGGA-100 100 µg
EUR 574.16
Syrian Hamster IgG Isotype Control
SIGGB-200 200 µg
EUR 472.24
Syrian Hamster IgG Isotype Control
SIGGF-200 200 µg
EUR 545.04
Syrian Hamster IgG Isotype Control
SIGGPE-100 100 µg
EUR 515.92
Syrian Hamster IgG Isotype Control
SIGGPP5.5-100 100 µg
EUR 676.08
Syrian Hamster IgG Isotype Control
SIGGPP5.5-25 25 µg
EUR 355.76
Syrian Hamster IgG Isotype Control
SIGGPU-500 500 µg
EUR 428.56
Goat IgG, purified (serum non-immune, isotype control)
20011-1 1 mg
EUR 141
Goat IgG, purified (serum non-immune, isotype control)
20011-25 25 mg
EUR 469
Goat IgG, purified (serum non-immune, isotype control)
20011-5 5 mg
EUR 286
Goat F(ab')2 IgG Isotype Control (FITC)
abx405077-100tests 100 tests
EUR 495
  • Shipped within 1 week.
Goat F(ab')2 IgG Isotype Control (RPE)
abx405078-05ml 0.5 ml
EUR 537
  • Shipped within 1 week.
Donkey IgG (Control, non-immune, isotype control)
20028-1 1 mg
EUR 164
Hamster IgG, purified (Syrian, isotype control)
20003-1 1 mg
EUR 141
Hamster IgG, purified (Armenian, Isotype control)
20003-1AH 1 mg
EUR 263
Human IgG-HRP Conjugate (isotype control)
20007-1-HP 500 ug
EUR 202
Mouse IgG-Biotin conjugate (isotype control)
20008-B 50 Tests
EUR 164
Mouse IgG-Biotin conjugate (isotype control)
20008-BT-1 1 mg
EUR 164
Mouse IgG-FITC conjugate (isotype control)
20008-F 100 tests
EUR 164
Mouse IgG-HRP conjugate (isotype control)
20008-HP 50 Tests
EUR 164
Mouse IgG-PE conjugate (isotype control)
20008-PE 50 Tests
EUR 164
Rabbit IgG-FITC conjugate (isotype control)
20009-F 100 ug
EUR 164
Rabbit IgG-HRP conjugate (isotype control)
20009-HP 100 ug
EUR 164
Rabbit IgG-PE conjugate (isotype control)
20009-PE 100 tests
EUR 225
Rabbit IgG Isotype Control APC Conjugate
APCCON 0.15 mg
EUR 261
Hamster (Arnenian) IgG Isotype Control (FITC)
abx405030-01mg 0.1 mg
EUR 384
  • Shipped within 1 week.
Hamster (Arnenian) IgG Isotype Control (RPE)
abx405031-01mg 0.1 mg
EUR 509
  • Shipped within 1 week.
Hamster (Syrian) IgG Isotype Control (FITC)
abx405033-01mg 0.1 mg
EUR 398
  • Shipped within 1 week.
Rabbit IgG Isotype Control FITC Conjugate
FITCCON 0.15 mg
EUR 261
Mouse IgG Isotype Control FITC Conjugate
MFITCCON 0.15 mg
EUR 261
Mouse IgG Isotype Control RPE Conjugate
MRPECON 0.15 mg
EUR 261
Mouse IgG Isotype Control PerCP Conjugate
MPERCPCON 0.15 mg
EUR 261
Mouse IgG Isotype Control APC Conjugate
MAPCCON 0.15 mg
EUR 261
Rabbit IgG Isotype Control PerCP Conjugate
PERCPCON 0.15 mg
EUR 261
Rabbit IgG Isotype Control RPE Conjugate
RPECON 0.15 mg
EUR 261
Donkey IgG (non-immune, isotype control) IgG, purified
20015-10 10 mg
EUR 286
Goat IgG control
31R-AG001 1 mg
EUR 127
Description: Goat Immunoglobulins Goat IgG control
Goat IgG Control
GT15900 1 mg
EUR 166
Llama IgG (Control, non-immune, isotype control, ELISA grade)
20030-1 1 mg
EUR 164
Camel IgG (Control, non-immune, isotype control, ELISA grade)
20031-1 1 mg
EUR 164
Alpaca IgG (Control, non-immune, isotype control, ELISA grade)
20032-1 1 mg
EUR 164
Hamster IgG-Biotin conjugate, isotype control (Syrian)
20003-1-B 100 test
EUR 164
Hamster IgG-Cy5 conjugate, isotype control (Syrian)
20003-1-Cy5 50 tests
EUR 225
Hamster IgG-FITC conjugate, isotype control (Syrian)
20003-1-F 100 tests
EUR 164
Hamster IgG-HRP conjugate, isotype control (Syrian)
20003-1-HP 100 tests
EUR 164
G. Pig IgG-Biotin conjugate (isotype control)
20004-B 100 ug
EUR 202
G. Pig IgG-FITC conjugate (isotype control)
20004-F 100 ug
EUR 202
G. Pig IgG-HRP conjugate (isotype control)
20004-HP 100 ug
EUR 202
Rat IgG Fab fragment, purified (isotype control)
20005-1-FAB 1 mg
EUR 164
Rat IgG (Fc) fragment, purified (isotype control)
20005-1-FC 0.5 mg
EUR 250

The macrophage activator GcMAF-RF, in accordance with its traits, corresponds to comparable preparations that are made accessible to the market by overseas firms, and may be thought-about as a brand new biologically lively preparation with a large spectrum of motion. Of biggest curiosity is its skill – via the activation of macrophages – to boost the adaptive immunity. In this regard, two areas of therapeutic use of the GcMAF-RF are proposed. The preparation shall be in demand in the subject of most cancers therapy, and, in addition, it may be used in the therapy of quite a few neurodegenerative pathologies. The early signs of nasopharyngeal carcinoma (NPC) are usually not apparent, and it’s troublesome to make early analysis. A case-control research was carried out to determine potential biomarkers and established a analysis mannequin for nasopharyngeal carcinoma.

Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

Locally superior urothelial cancer has excessive recurrence and progression charges following surgical remedy. This highlights the necessity to develop neoadjuvant methods which are each efficient and well-tolerated. We hypothesized that neoadjuvant sub-ablative vascular-targeted photodynamic therapy (sbVTP), by way of its immunotherapeutic mechanism, would enhance survival and scale back recurrence and progression in a murine model of urothelial cancer. After urothelial tumor implantation and 17 days earlier than surgical resection, mice acquired neoadjuvant sbVTP (WST11; Tookad Soluble, Steba Biotech, France). Local and systemic response and survival served as measures of therapeutic efficacy, whereas immunohistochemistry and move cytometry elucidated the immunotherapeutic mechanism. Data evaluation included two-sided Kaplan-Meier, Mann-Whitney, and Fischer actual checks.

Tumor quantity was considerably smaller in sbVTP-treated animals than in controls (135 mm3 vs. 1222 mm3, P < 0.0001) on the day of surgical procedure. Systemic progression was considerably decrease in sbVTP-treated animals (l7% vs. 30%, P < 0.01). Both median progression-free survival and general survival have been considerably larger amongst animals that acquired sbVTP and surgical procedure than amongst animals that acquired surgical procedure alone (P < 0.05). Neoadjuvant-treated animals additionally demonstrated considerably decrease native recurrence. Neoadjuvant sbVTP was related to elevated early antigen-presenting cells, and subsequent enhancements in long-term reminiscence and will increase in effector and energetic T-cells in the spleen, lungs, and blood.

In abstract, neoadjuvant sbVTP delayed native and systemic progression, extended progression-free and general survival, and decreased native recurrence, thereby demonstrating therapeutic efficacy by way of an immune-mediated response. These findings strongly assist its analysis in scientific trials. The Taiwan Smell Identification Test (TWSIT) was developed and efficiently administered in Taiwanese inhabitants since 2015. However, for sanitation cause, the unique liquid-jar type of this take a look at will not be applicable. The commercialized TWSIT was then re-designed as “scratch-and-sniff” model: the TIBSIT (Top International Biotech, Taipei, Taiwan). This mission goals to analyze the normative worth of TIBSIT in totally different age teams and genders.

Clinical Performance and Analytical Sensitivity of Three SARS-CoV-2 Nucleic Acid Diagnostic Tests

Hundreds of RT-qPCR kits can be found in the marketplace for SARS-CoV-2 prognosis, some of them with emergency use authorization (EUA) by the Food Drug Administration (FDA) or their nation of origin company, but additionally many of them with none impartial scientific efficiency analysis. We carried out a scientific analysis for 2 Chinese SARS-CoV-2 RT-PCR kits out there in South America, COVID-19 Nucleic Acid Test Kit (eDiagnosis Biomedicine, Wuhan, China) and 2019-nCoV Nucleic Acid Diagnostic Kit (Sansure Biotech, Changsha, China), for RT-qPCR SARS-CoV-2 prognosis utilizing the FDA EUA 2019-nCoV CDC package (IDT, Coralville, IA) as gold normal.

We discovered a superb scientific efficiency and analytical sensitivity for each kits with sensitivity values of 100% and 95.3% and estimated restrict of detection of 500 copies/mL and 1,000 copies/mL, for eDiagnosis and Sansure Biotech kits, respectively. COVID-19 Nucleic Acid Test Kit (eDiagnosis) and 2019-nCoV Nucleic Acid Diagnostic Kit (Sansure Biotech) are each made in China and maintain EUA by the Chinese CDC. Also, Sansure Biotech package has EUA by the FDA. In conclusion, our outcomes endorse the use of these two commercially out there kits imported to Ecuador for SARS-CoV-2 prognosis, as that they had the same scientific efficiency because the gold normal from the CDC.

With a globally ageing inhabitants, longevity is turning into essentially the most promising marketplace for the biotech trade. In animals, ageing may be retarded and longevity prolonged, which, if translated to people, would end result in large well being advantages with exceptional business worth. The potential to decelerate human ageing has led to a race to find essentially the most promising longevity medication in animals and in the end translate them to people. Indeed, in current years, there was exponential progress in longevity medication found in animal fashions. Investment in longevity biotech can be booming, and a number of scientific trials will quickly make clear which medication prolong wholesome lives. Thus, the longevity pharmacology subject guarantees to revolutionize the healthcare of a rising ageing inhabitants.

Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

Green recycling course of for polyurethane foams by a chem-biotech method

Polyurethanes are extremely resistant supplies used for constructing insulation or automotive seats. The polyurethane end-of-life concern have to be addressed by the event of environment friendly recycling methods. Since typical recycling processes aren’t appropriate for thermosets, waste administration of PU foam is especially questioning. By coupling organic and chemical processes, this examine goals at growing a inexperienced recycling pathway for PU foam utilizing enzymes for depolymerization. For occasion, enzymatic degradation of a PU foam synthesized with polycaprolactone and toluene diisocyanate led to a weight reduction of 25 % after 24 h of incubation.

Positive control tissue section for each antibody; Based on availability INQUIRE

Control-Slides Set of 5
EUR 176

EF1a control lentivirus (Hygro)

EF1a-Null-Hygro 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

EF1a control lentivirus (Zeo)

EF1a-Null-Zeo 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

CMV control lentivirus (Hygro)

CMV-Null-Hygro 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

CMV control lentivirus (Zeo)

CMV-Null-Zeo 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

GFP Expressing Human Glioblastoma Cells

TR01-GFP 500,000 Cells
EUR 1354

GFP Expressing Human Gastric Carcinoma N87 Cells

TR02-GFP 500,000 Cells
EUR 1354

GFP Expressing Human Renal Adenocarcinoma Cells (ACHN)

TR04-GFP 500,000 Cells
EUR 1354

GFP Expressing Human Prostate Carcinoma Cells (DU 145)

TR03-GFP 500,000 Cells
EUR 1354

Lenti-HOXA10-GFP Lentivirus

LV646 10 ml
EUR 811

Lenti-HOXB8-GFP Lentivirus

LV634 10 ml
EUR 811

Lenti-HOXA9-GFP Lentivirus

LV640 10 ml
EUR 811

ISRE-Luc (GFP) Lentivirus 

LVP939-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter undera minimal promoter embeded 8 tandem repeats of ISRE (Interferon Stimulated Response Element). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ISRE-Rluc (GFP) Lentivirus 

LVP940-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter undera minimal promoter embeded 8 tandem repeats of ISRE (Interferon Stimulated Response Element). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-GFP (Bsd) Lentivirus 

LVP941-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-GFP (Neo) Lentivirus 

LVP941-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-GFP (Puro) Lentivirus 

LVP941-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-GFP (RFP) Lentivirus 

LVP941-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-RFP (GFP) Lentivirus 

LVP942-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-Luc (GFP) Lentivirus 

LVP943-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-Rluc (GFP) Lentivirus 

LVP944-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-GFP (Bsd) Lentivirus 

LVP945-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-GFP (Neo) Lentivirus 

LVP945-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-GFP (Puro) Lentivirus 

LVP945-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-GFP (RFP) Lentivirus 

LVP945-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-RFP (GFP) Lentivirus 

LVP946-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-Luc (GFP) Lentivirus 

LVP947-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-Rluc (GFP) Lentivirus 

LVP948-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-GFP (Bsd) Lentivirus 

LVP949-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-GFP (Neo) Lentivirus 

LVP949-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-GFP (Puro) Lentivirus 

LVP949-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-GFP (RFP) Lentivirus 

LVP949-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-RFP (GFP) Lentivirus 

LVP950-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-Luc (GFP) Lentivirus 

LVP951-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-Rluc (GFP) Lentivirus 

LVP952-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-GFP (Bsd) Lentivirus 

LVP953-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-GFP (Neo) Lentivirus 

LVP953-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-GFP (Puro) Lentivirus 

LVP953-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-GFP (RFP) Lentivirus 

LVP953-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-RFP (GFP) Lentivirus 

LVP954-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-Luc (GFP) Lentivirus 

LVP955-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-Rluc (GFP) Lentivirus 

LVP956-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-GFP (Bsd) Lentivirus 

LVP957-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-GFP (Neo) Lentivirus 

LVP957-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-GFP (Puro) Lentivirus 

LVP957-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-GFP (RFP) Lentivirus 

LVP957-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-RFP (GFP) Lentivirus 

LVP958-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-Luc (GFP) Lentivirus 

LVP959-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-Rluc (GFP) Lentivirus 

LVP960-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-GFP (Bsd) Lentivirus 

LVP961-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-GFP (Neo) Lentivirus 

LVP961-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-GFP (Puro) Lentivirus 

LVP961-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-GFP (RFP) Lentivirus 

LVP961-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-RFP (GFP) Lentivirus 

LVP962-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-Luc (GFP) Lentivirus 

LVP963-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-Rluc (GFP) Lentivirus 

LVP964-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-GFP (Bsd) Lentivirus 

LVP965-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-GFP (Neo) Lentivirus 

LVP965-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-GFP (Puro) Lentivirus 

LVP965-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-GFP (RFP) Lentivirus 

LVP965-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-RFP (GFP) Lentivirus 

LVP966-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-Luc (GFP) Lentivirus 

LVP967-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-Rluc (GFP) Lentivirus 

LVP968-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-GFP (Bsd) Lentivirus 

LVP969-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-GFP (Neo) Lentivirus 

LVP969-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-GFP (Puro) Lentivirus 

LVP969-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-GFP (RFP) Lentivirus 

LVP969-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-RFP (GFP) Lentivirus 

LVP970-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-Luc (GFP) Lentivirus 

LVP971-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-Rluc (GFP) Lentivirus 

LVP972-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-GFP (Bsd) Lentivirus 

LVP973-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-GFP (Neo) Lentivirus 

LVP973-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-GFP (Puro) Lentivirus 

LVP973-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-GFP (RFP) Lentivirus 

LVP973-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-RFP (GFP) Lentivirus 

LVP974-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-Luc (GFP) Lentivirus 

LVP975-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-Rluc (GFP) Lentivirus 

LVP976-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-GFP (Bsd) Lentivirus 

LVP977-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-GFP (Neo) Lentivirus 

LVP977-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-GFP (Puro) Lentivirus 

LVP977-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-GFP (RFP) Lentivirus 

LVP977-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-RFP (GFP) Lentivirus 

LVP978-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-Luc (GFP) Lentivirus 

LVP979-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-Rluc (GFP) Lentivirus 

LVP980-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-GFP (Bsd) Lentivirus 

LVP981-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-GFP (Neo) Lentivirus 

LVP981-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-GFP (Puro) Lentivirus

LVP981-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-GFP (RFP) Lentivirus 

LVP981-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-RFP (GFP) Lentivirus 

LVP982-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-Luc (GFP) Lentivirus 

LVP983-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-Rluc (GFP) Lentivirus 

LVP984-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-GFP (Bsd) Lentivirus 

LVP985-B 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the Blasticidin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-GFP (Neo) Lentivirus 

LVP985-N 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the Neomycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-GFP (Puro) Lentivirus 

LVP985-P 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the puromycin selection marker under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-GFP (RFP) Lentivirus 

LVP985-R 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express GFP reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the RFP selection marker under the constitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-RFP (GFP) Lentivirus 

LVP986-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-Luc (GFP) Lentivirus 

LVP987-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-Rluc (GFP) Lentivirus 

LVP988-G 1x107 IFU/ml x 200ul
EUR 552
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

The corresponding degradation merchandise have been recovered and recognized as 6-hydroxycaproic acid and a quick acid-terminated diurethane. An organo-metallic catalyzed synthesis of second technology polymers from these constructing blocks was carried out. A polymer with a excessive common molar mass of 74 000 (Mw) was obtained by mixing 50 % of recycled constructing blocks and 50 % of neat 6-hydroxycaproic acid. A poly(ester urethane) have been synthesized with out the use of poisonous and decrier polyisocyanates. It is the primary time that a examine provides the imaginative and prescient of a recycling loop ranging from PU wastes and ending with a second technology polymer in a full round method.

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

ConspectusAntimicrobial resistance to present antibiotics represents one of many best threats to human well being and is rising at an alarming price. To additional complicate therapy of bacterial infections, many power infections are the results of bacterial biofilms which are tolerant to therapy with antibiotics due to the presence of metabolically dormant persister cell populations. Together these threats are creating an rising burden on the healthcare system, and a “preantibiotic” age is on the horizon if vital motion will not be taken by the scientific and medical communities. While the golden period of antibiotic discovery (1940s-1960s) produced a lot of the antibiotic courses in scientific use at this time, adopted by a number of many years of restricted growth, there was a resurgence in antibiotic drug discovery lately fueled by the tutorial and biotech sectors.

Historically, nice success has been achieved by growing next-generation variants of present courses of antibiotics, however there stays a dire want for the identification of novel scaffolds and/or antimicrobial targets to drive future efforts to overcome resistance and tolerance. In this regard, there was no extra priceless supply for the identification of antibiotics than pure merchandise, with 69-77% of accepted antibiotics both being such compounds or being derived from them.Our group has developed a program centered on the chemical synthesis and chemical microbiology of marine pure merchandise with uncommon buildings and promising ranges of exercise towards multidrug-resistant (MDR) bacterial pathogens.

As we’re motivated by making ready and finding out the organic results of those molecules, we aren’t initially pursuing a organic query however as an alternative are permitting the noticed phenotypes and actions to information the last word challenge path. In this Account, our latest efforts on the synoxazolidinone, lipoxazolidinone, and batzelladine pure merchandise might be mentioned and positioned within the context of the sphere’s best challenges and alternatives. Specifically, the synoxazolidinone household of 4-oxazolidinone-containing pure merchandise has led to the event of a number of chemical strategies to put together antimicrobial scaffolds and has revealed compounds with potent exercise as adjuvants to deal with bacterial biofilms. Bearing the identical 4-oxazolidinone core, the lipoxazolidinones have confirmed to be potent single-agent antibiotics.

Finally, our artificial efforts towards the batzelladines revealed analogues with exercise towards a variety of MDR pathogens, highlighted by non-natural stereochemical isomers with superior exercise and simplified artificial entry. Taken collectively, these research present a number of distinct platforms for the event of novel therapeutics that may add to our arsenal of scaffolds for preclinical growth and can present perception into the biochemical processes and pathways that may be focused by small molecules within the battle towards antimicrobial-resistant and -tolerant infections. We hope that this work will serve as inspiration for elevated efforts by the scientific neighborhood to leverage artificial chemistry and chemical microbiology towards novel antibiotics that may fight the rising disaster of MDR and tolerant bacterial infections.

Life sciences mental property licensing on the Massachusetts Institute of Technology

Academic establishments play a central position within the biotech trade by means of know-how licensing and the creation of startups, however few information can be found on their efficiency and the magnitude of their affect. Here we current a systematic research of know-how licensing by one such establishment, the Massachusetts Institute of Technology (MIT). Using information on the 76 therapeutics-focused life sciences corporations shaped by means of MIT’s Technology Licensing Office from 1983 to 2017, we assemble a number of measures of affect, together with MIT patents cited within the Orange Book

capital raised, outcomes from mergers and acquisitions, patents granted to MIT mental property licensees, drug candidates found and US drug approvals-a key benchmark of innovation within the biopharmaceutical trade. As of December 2017, Orange Book listings for 4 accepted small-molecule medicine cite MIT patents, however one other 31 FDA-approved medicine (excluding candidates acquired after section 3) had some involvement of MIT licensees. Fifty-five % of the latter had been both a new molecular entity or a new organic entity, and 55% had been granted precedence evaluate, a sign that they handle an unmet medical want.

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

Recent Advances within the Evaluation of Serological Assays for the Diagnosis of SARS-CoV-2 Infection and COVID-19

Few information on the diagnostic efficiency of serological exams for extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) an infection are presently out there. We evaluated sensitivity and specificity of 5 completely different extensively used industrial serological assays for the detection of SARS-CoV-2-specific IgG, IgM, and IgA antibodies utilizing reverse transcriptase-PCR assay in nasopharyngeal swab as reference customary take a look at. The methodology described right here could also be a helpful framework for different educational establishments to monitor outcomes of mental property within the therapeutics area

A complete of 337 plasma samples collected within the interval April-June 2020 from SARS-CoV-2 RT-PCR optimistic (n = 207) and destructive (n = 130) topics had been investigated by one point-of-care lateral stream immunochromatographic assay (LFIA IgG and IgM, Technogenetics) and 4 totally automated assays: two chemiluminescence immunoassays (CLIA-iFlash IgG and IgM, Shenzhen YHLO Biotech and CLIA-LIAISON XL IgG, DiaSorin), one electrochemiluminescence immunoassay (ECLIA-Elecsys® whole predominant IgG, Roche), and one enzyme-linked immunosorbent assay (ELISA IgA, Euroimmune.

Mouse IgG2a Isotype Control

abx200572-100ug 100 ug
EUR 314
  • Shipped within 3-5 working days.

Mouse IgG2a Isotype Control

abx139004-01mg 0.1 mg
EUR 314
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control

abx139005-01mg 0.1 mg
EUR 314
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control

abx139009-01mg 0.1 mg
EUR 314
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control

abx405013-100tests 100 tests
EUR 411
  • Shipped within 1 week.

Mouse IgG2a Isotype Control

abx405015-05mg 0.5 mg
EUR 690
  • Shipped within 1 week.

Mouse IgG2a Isotype Control

abx405018-1mg 1 mg
EUR 1107
  • Shipped within 1 week.

Mouse IgG2a Isotype Control

abx405070-100tests 100 tests
EUR 411
  • Shipped within 1 week.

Mouse IgG2a Isotype Control

abx405073-05mg 0.5 mg
EUR 829
  • Shipped within 1 week.

Mouse IgG2a isotype control, purified

20102-102 100 ug
EUR 141

Mouse IgG2a Isotype Control Purified

11-458-C025 0.025 mg
EUR 88

Mouse IgG2a Isotype Control Purified

11-458-C100 0.1 mg
EUR 136

Mouse IgG2a Isotype Control Purified

11-724-C025 0.025 mg
EUR 88

Mouse IgG2a Isotype Control Purified

11-724-C100 0.1 mg
EUR 136

Mouse IgG2a Isotype Control APC

1A-724-C025 0.025 mg
EUR 122

Mouse IgG2a Isotype Control APC

1A-724-C100 0.1 mg
EUR 204

Mouse IgG2a Isotype Control Biotin

1B-724-C025 0.025 mg
EUR 108

Mouse IgG2a Isotype Control Biotin

1B-724-C100 0.1 mg
EUR 177

Mouse IgG2a Isotype Control FITC

1F-724-C025 0.025 mg
EUR 108

Mouse IgG2a Isotype Control FITC

1F-724-C100 0.1 mg
EUR 177

Mouse IgG2a Isotype Control PE

1P-724-C025 0.025 mg
EUR 122

Mouse IgG2a Isotype Control PE

1P-724-C100 0.1 mg
EUR 204

Mouse IgG2a Isotype Control (FITC)

abx200573-100ug 100 ug
EUR 314
  • Shipped within 3-5 working days.

Mouse IgG2a Isotype Control (PE)

abx200574-50ug 50 ug
EUR 425
  • Shipped within 3-5 working days.

Mouse IgG2a Isotype Control (APC)

abx200575-50ug 50 ug
EUR 425
  • Shipped within 3-5 working days.

Mouse IgG2a Isotype Control (PerCP)

abx200576-100ug 100 ug
EUR 425
  • Shipped within 2-3 weeks.

Mouse IgG2a Isotype Control (APC)

abx139012-01mg 0.1 mg
EUR 425
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (Biotin)

abx139013-01mg 0.1 mg
EUR 384
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (FITC)

abx139014-01mg 0.1 mg
EUR 384
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (PE)

abx139015-01mg 0.1 mg
EUR 425
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (PerCP)

abx139016-01mg 0.1 mg
EUR 425
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (Biotin)

abx405014-01mg 0.1 mg
EUR 411
  • Shipped within 1 week.

Mouse IgG2a Isotype Control (FITC)

abx405016-01mg 0.1 mg
EUR 509
  • Shipped within 1 week.

Mouse IgG2a Isotype Control (RPE)

abx405017-100tests 100 tests
EUR 634
  • Shipped within 1 week.

Mouse IgG2a Isotype Control (APC)

abx405071-100tests 100 tests
EUR 425
  • Shipped within 1 week.

Mouse IgG2a Isotype Control (Biotin)

abx405072-100tests 100 tests
EUR 411
  • Shipped within 1 week.

Mouse IgG2a Isotype Control (FITC)

abx405074-100tests 100 tests
EUR 411
  • Shipped within 1 week.

Mouse IgG2a Isotype Control (RPE)

abx405075-100tests 100 tests
EUR 467
  • Shipped within 1 week.

Mouse IgG2a Isotype control; Concentrate

NG905C 1 ml
EUR 357

Mouse IgG2a FITC (isotype control)

MG2bF-25 25 Tests
EUR 225

Mouse IgG2a Isotype Control PerCP

PC-724-C025 0.025 mg
EUR 122

Mouse IgG2a Isotype Control PerCP

PC-724-C100 0.1 mg
EUR 204

Rat IgG2a Isotype Control

11-168-C025 0.025 mg
EUR 87

Rat IgG2a Isotype Control

abx200644-500ug 500 ug
EUR 481
  • Shipped within 3-5 working days.

Rat IgG2a Isotype Control

abx405022-1ml 1 ml
EUR 300
  • Shipped within 1 week.

Rat IgG2a Isotype Control

abx405024-05mg 0.5 mg
EUR 384
  • Shipped within 1 week.

Rat IgG2a Isotype Control

abx405027-1mg 1 mg
EUR 565
  • Shipped within 1 week.

Rat IgG2a Isotype Control

abx405045-05mg 0.5 mg
EUR 384
  • Shipped within 1 week.

Rat IgG2a Isotype Control

20-abx405047
  • EUR 300.00
  • EUR 439.00
  • 0.1 mg
  • 1 mg
  • Shipped within 1 week.

Rat IgG2a Isotype Control

RIGG2AA-100 100 µg
EUR 312.08

Rat IgG2a Isotype Control

RIGG2AA-25 25 µg
EUR 181.04

Rat IgG2a Isotype Control

RIGG2AB-200 200 µg
EUR 457.68

Rat IgG2a Isotype Control

RIGG2AB-50 50 µg
EUR 224.72

Rat IgG2a Isotype Control

RIGG2AF-200 200 µg
EUR 312.08

Rat IgG2a Isotype Control

RIGG2AF-50 50 µg
EUR 166.48

Rat IgG2a Isotype Control

RIGG2APE-100 100 µg
EUR 282.96

Rat IgG2a Isotype Control

RIGG2APE-25 25 µg
EUR 166.48

Rat IgG2a Isotype Control

RIGG2APP-100 100 µg
EUR 574.16

Rat IgG2a Isotype Control

RIGG2APP-25 25 µg
EUR 268.4

Rat IgG2a Isotype Control

RIGG2APP5.5-100 100 µg
EUR 646.96

Rat IgG2a Isotype Control

RIGG2APP5.5-25 25 µg
EUR 282.96

Rat IgG2a Isotype Control

RIGG2APU-50 50 µg
EUR 181.04

Rat IgG2a Isotype Control

RIGG2APU-500 500 µg
EUR 399.44

Mouse IgG2a (FITC) / Mouse IgG2a (RPE) Isotype Control

abx405002-50tests 50 tests
EUR 620
  • Shipped within 1 week.

Mouse IgG2a-Biotin conjugate (isotype control)

20102-102-B 50 Tests
EUR 164

Mouse IgG2a-FITC conjugate (isotype control)

20102-102-F 50 tests
EUR 164

Mouse IgG2a-HRP conjugate (isotype control)

20102-102-HP 50 Tests
EUR 164

Mouse IgG2a-PE conjugate (isotype control)

20102-102-PE 50 Tests
EUR 164

Mouse IgG2a Isotype Control (CF-Blue)

abx200577-100ug 100 ug
EUR 425
  • Shipped within 3-5 working days.

Mouse IgG2a Isotype Control (OC-515)

abx200578-100ug 100 ug
EUR 481
  • Shipped within 2-3 weeks.

Mouse IgG2a Isotype Control (APC-C750)

abx200579-50ug 50 ug
EUR 787
  • Shipped within 2-3 weeks.

Mouse IgG2a Isotype Control (Azide free)

abx139007-01mg 0.1 mg
EUR 314
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control Alexa Fluor488

A4-458-C025 0.025 mg
EUR 149

Mouse IgG2a Isotype Control Alexa Fluor488

A4-458-C100 0.1 mg
EUR 258

Mouse IgG2a Isotype Control Alexa Fluor488

A4-724-C025 0.025 mg
EUR 149

Mouse IgG2a Isotype Control Alexa Fluor488

A4-724-C100 0.1 mg
EUR 258

Mouse IgG2a Isotype Control Alexa Fluor647

A6-458-C025 0.025 mg
EUR 149

Mouse IgG2a Isotype Control Alexa Fluor647

A6-458-C100 0.1 mg
EUR 258

Mouse IgG2a Isotype Control Alexa Fluor647

A6-724-C025 0.025 mg
EUR 149

Mouse IgG2a Isotype Control Alexa Fluor647

A6-724-C100 0.1 mg
EUR 258

Mouse IgG2a Isotype Control Alexa Fluor700

A7-724-C025 0.025 mg
EUR 149

Mouse IgG2a Isotype Control Alexa Fluor700

A7-724-C100 0.1 mg
EUR 258

Mouse IgG2a Isotype Control Pacific Blue

PB-724-C025 0.025 mg
EUR 139

Mouse IgG2a Isotype Control Pacific Blue

PB-724-C100 0.1 mg
EUR 238

Rat IgG2a unconjugated (isotype control)

20005-12 100 ug
EUR 164

Rat IgG2a Isotype Control Purified

11-168-C100 0.1 mg
EUR 136

Rat IgG2a Isotype Control PE

1P-168-C025 0.025 mg
EUR 122

Rat IgG2a Isotype Control PE

1P-168-C100 0.1 mg
EUR 204

Rat IgG2a Isotype Control (Biotin)

abx405023-01mg 0.1 mg
EUR 314
  • Shipped within 1 week.

Rat IgG2a Isotype Control (FITC)

abx405025-100tests 100 tests
EUR 342
  • Shipped within 1 week.

Rat IgG2a Isotype Control (RPE)

abx405026-100tests 100 tests
EUR 356
  • Shipped within 1 week.

Rat IgG2a Isotype Control (APC)

abx405043-100tests 100 tests
EUR 425
  • Shipped within 1 week.

Rat IgG2a Isotype Control (Biotin)

abx405044-01mg 0.1 mg
EUR 314
  • Shipped within 1 week.

Rat IgG2a Isotype Control (FITC)

abx405046-01mg 0.1 mg
EUR 342
  • Shipped within 1 week.

Rat IgG2a Isotype Control (RPE)

abx405048-100tests 100 tests
EUR 356
  • Shipped within 1 week.

Rat IgG2a (FITC) / Rat IgG2a (RPE) Isotype Control

abx405004-100tests 100 tests
EUR 634
  • Shipped within 1 week.

Mouse IgG2a-PE-Cy5 conjugate (isotype control)

20102-102-PC5 50 Tests
EUR 225

Mouse IgG2a Isotype Control, FITC Conjugated mAb

28274-50Tests 50 Tests
EUR 252

Mouse IgG2a Isotype Control, PE Conjugated mAb

28275-50Tests 50 Tests
EUR 252

The general sensitivity of all IgG serological assays was >80% and the specificity was >97%. The sensitivity of IgG assays was decrease inside 2 weeks from the onset of signs starting from 70.8 to 80%. The LFIA and CLIA-iFlash IgM confirmed an general low sensitivity of 47.6 and 54.6%, whereas the specificity was 98.5 and 96.2%, respectively. The ELISA IgA yielded a sensitivity of 84.3% and specificity of 81.7%. However, the ELISA IgA consequence was indeterminate in 11.7% of circumstances.