Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

ConspectusAntimicrobial resistance to present antibiotics represents one of many best threats to human well being and is rising at an alarming price. To additional complicate therapy of bacterial infections, many power infections are the results of bacterial biofilms which are… Continue Reading

Evaluation of 18 commercial serological assays for the detection of antibodies against SARS-CoV-2 in paired serum samples

Evaluation of 18 commercial serological assays for the detection of antibodies against SARS-CoV-2 in paired serum samples

A range of serological checks have been developed to detect the presence of antibodies against the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluated the efficiency of 18 commercially accessible SARS-CoV-2 antibody assays. Early (6-Eight days after the begin… Continue Reading

First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial.

First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial.

BACKGROUNDBisphosphonates scale back the danger of skeletal occasions in sufferers with malignant bone illness, and zoledronic acid has proven potential anticancer results in preclinical and medical research. We aimed to ascertain whether or not bisphosphonates can have an effect on… Continue Reading

The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs.

The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs.

Despite a number of modern medicines gaining worldwide approval in current years, there are nonetheless therapeutic areas for which unhappy therapeutic wants persist. For instance, excessive unmet scientific want was noticed in sufferers identified with kind 2 diabetes mellitus and… Continue Reading

What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Liposomes are thought of one of the profitable drug supply techniques (DDS) given their established utility and success within the clinic. In the previous 40⁻50 years, Canadian scientists have made ground-breaking discoveries, lots of which have been efficiently translated to… Continue Reading