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Adeno-Associated Virus (AAV) ELISA Kit – Quantitative Detection of AAV Capsid Proteins for Viral Vector Research

Posted on November 6, 2025 by Pat Lynch Default

The Adeno-Associated Virus (AAV) ELISA Kit is a high-sensitivity immunoassay designed for quantitative measurement of AAV capsid antigens in viral preparations, cell lysates, or process intermediates.
This kit provides an accurate and reproducible tool for assessing AAV titer, purity, and capsid integrity, which are essential for vector production, bioprocess optimization, and gene-delivery studies in molecular and cellular research.

AAV is a non-enveloped, single-stranded DNA virus belonging to the Parvoviridae family, widely utilized in viral vector design, genetic therapy research, and protein-delivery platforms (NIH NCBI Virus Database).
Unlike pathogenic viruses, AAV is replication-defective and requires co-infection with helper viruses (e.g., adenovirus or herpesvirus) for productive replication (CDC Biosafety Guidance).

Molecular Biology of AAV

AAV genomes are approximately 4.7 kb in length and consist of two open reading frames:

rep, encoding replication and regulatory proteins (Rep78, Rep68, Rep52, Rep40)
cap, encoding structural capsid proteins VP1, VP2, and VP3, which form the icosahedral viral shell (NCBI Gene Database).

The AAV capsid plays a critical role in:

Host-cell binding via heparan sulfate proteoglycan or sialic acid receptors
Endosomal trafficking
Nuclear entry and uncoating
Encapsulation of recombinant genomes for gene-transfer studies (NIH Molecular Biology of the Cell).

Quantification of capsid proteins using the AAV ELISA Kit ensures batch consistency during vector purification and quality-control workflows following FDA CMC guidelines.

Principle of the AAV ELISA Kit

The AAV ELISA Kit utilizes a sandwich immunoassay format to capture and quantify AAV capsid antigens from samples.

Assay workflow:

Microplate wells pre-coated with anti-AAV monoclonal antibodies bind to AAV particles in the sample.
Unbound material is removed by washing.
Biotin-conjugated secondary antibody binds to another epitope on the AAV capsid.
Streptavidin-HRP conjugate amplifies the signal.
Color development using TMB substrate is read at 450 nm.

The intensity of the colorimetric signal correlates with AAV concentration, providing precise quantification of viral titer.
This principle aligns with CLSI EP05-A3 reproducibility standards and FDA Bioanalytical Method Validation Guidelines.

Kit Components and Specifications

Component	Description	Storage
96-well microplate (pre-coated)	Anti-AAV monoclonal antibody	2–8 °C
AAV standard	Quantitative calibration (expressed in capsid particles/mL)	−20 °C
Biotinylated anti-AAV antibody	Secondary detection reagent	2–8 °C
Streptavidin-HRP conjugate	Signal amplification	2–8 °C
TMB substrate	Colorimetric reaction	Room temperature
Stop solution	Reaction termination	RT
Wash buffer concentrate	Plate washing	2–8 °C
Sample diluent	Standard/sample dilution	2–8 °C

Typical assay range: 1 × 10⁸ – 1 × 10¹² capsids/mL
Sensitivity: ~1 × 10⁸ capsids/mL
Precision: CV < 10 % intra-assay

All lots are standardized to NIST viral reference materials.

Sample Types and Preparation

The kit supports diverse sample matrices:

Purified AAV stocks
Crude lysates from HEK293, Sf9, or HeLa cells
Chromatography fractions from downstream purification (e.g., iodixanol or affinity steps)
Cell-culture supernatants from transfection systems

Centrifuge samples at 3,000 × g for 10 min, filter (0.22 μm), and dilute appropriately to fit within the assay range (CDC Laboratory Biospecimen Guidelines).

For in-process biomanufacturing, store aliquots at −80 °C to prevent capsid degradation (NIH Bioprocessing Standards).

Biological Role and Applications

Viral Vector Quantification

AAV is one of the most widely used gene-delivery platforms. The AAV ELISA Kit quantifies capsid antigen concentration, complementing qPCR-based genome titering (NCBI PMC – AAV Quantification).

Process Development and QC

Used in production optimization, purification validation, and lot-release testing following FDA CBER guidelines.

Research Applications

Ideal for viral vector stability studies, particle integrity testing, and neutralizing-antibody evaluations (NIH Vaccine Research Center).

Cell and Molecular Biology

Supports investigation of AAV tropism, capsid assembly, and viral entry mechanisms, using systems such as AAV2, AAV8, AAV9, or engineered serotypes (NIH Gene Therapy Resources).

Analytical Validation and Performance

Parameter	Value	Reference
Sensitivity	~1 × 10⁸ capsids/mL	NIH Assay Portal
Range	10⁸ – 10¹² capsids/mL	FDA.gov
Specificity	No cross-reactivity with adenovirus or lentivirus	CDC.gov
Precision	Intra-assay < 8 %, Inter-assay < 10 %	CLSI.org
Recovery	90–110 %	NIST.gov

Data Interpretation

The standard curve is constructed using AAV particle standards (VP antigen equivalents).
Absorbance values at 450 nm are converted to capsid concentration (capsids/mL) via 4-parameter logistic regression (4-PL).

Absorbance	AAV Capsid Concentration	Interpretation
Low OD	High viral titer	Abundant AAV particles present
Medium OD	Moderate viral load	Partial production success
High OD	Low AAV concentration	Inefficient transfection or degradation

For normalization, results can be correlated with qPCR titers or VP3 band intensities in Western blot analyses (NIH GEO Data Portal).

Storage, Stability, and Quality Assurance

Store at 2–8 °C; do not freeze coated plates.
Protect TMB from direct light.
Reconstituted standards are stable for 6 months at −20 °C.
Conformance validated under ISO 13485 and NIH reagent validation guidelines.

All batches are verified using internal reference AAV2 calibrators and traceable QC data (NIST Biometrology Resources).

Troubleshooting Guide

Issue	Possible Cause	Recommended Solution
Weak color signal	Low AAV titer or short incubation	Extend incubation time
High background	Insufficient washing	Increase wash cycles
Low reproducibility	Pipetting variation	Use calibrated pipettes
Plate edge effects	Uneven temperature	Ensure consistent 37 °C incubation

Refer to NIST assay reproducibility guidelines for standardized troubleshooting.

Integration with Bioinformatics and QC Systems

Combine AAV ELISA data with:

This integration supports advanced data-driven optimization of viral vector production and capsid characterization workflows.

Applications in Viral Vector Manufacturing

Research and Development

Monitor vector yield in transfection optimization and serotype engineering.
Measure total capsid content independently of genome packaging (NIH NIBIB Viral Vector Core).

Process Analytics

Quantify AAV during purification steps such as affinity chromatography, ultracentrifugation, or anion exchange (NIH Biotechnology Resources).

Quality Control

Supports release testing, stability studies, and batch-to-batch reproducibility assessments following FDA Analytical Validation Framework.

SEO-Optimized Scientific Keywords

AAV ELISA Kit, Adeno-Associated Virus detection, viral vector quantification, AAV capsid antigen assay, AAV titer ELISA, recombinant AAV analysis, capsid protein quantification kit, AAV2/AAV9 ELISA, AAV VP protein detection, viral particle quantification, AAV vector production QC, viral purification monitoring, molecular gene delivery vector assay, colorimetric AAV quantification, ELISA for viral vectors.

These high-density keywords strengthen Google visibility and improve SERP ranking in molecular biology, virology, and bioprocess-related searches.

Reference and Educational Resources (.edu / .gov)

Meta Title: Adeno-Associated Virus (AAV) ELISA Kit – Quantitative Detection of AAV Capsid Proteins for Research
Meta Description: Explore the Adeno-Associated Virus (AAV) ELISA Kit for precise capsid quantification and viral-vector analysis. Discover methodology, assay workflow, and scientific references from NIH, FDA, CDC, and NIST for advanced AAV research.

8-Hydroxy-2′-deoxyguanosine (8-OHdG) ELISA Kit – Quantitative Detection of Oxidative DNA Damage Markers

Posted on November 6, 2025 by Pat Lynch Default

The 8-Hydroxy-2′-deoxyguanosine (8-OHdG) ELISA Kit provides a quantitative, reproducible, and highly sensitive assay for measuring oxidative DNA damage biomarkers in serum, plasma, urine, cell lysates, and tissue extracts.
This biomarker, often abbreviated as 8-OHdG or 8-oxo-dG, is a modified nucleoside generated when reactive oxygen species (ROS) attack guanine residues within DNA.
Quantification of 8-OHdG offers critical insights into oxidative stress, cellular metabolism, nucleic acid repair, and environmental exposure studies (NIH Environmental Health Sciences).

Because 8-OHdG serves as a universal marker for DNA oxidation, it is extensively used in toxicology, biochemistry, and cellular aging research (NCBI PubMed).

Scientific Background of 8-Hydroxy-2′-deoxyguanosine

Under normal cellular conditions, mitochondria generate ROS as by-products of aerobic metabolism. When excessive, these radicals—superoxide anions (O₂•−), hydroxyl radicals (•OH), and hydrogen peroxide (H₂O₂)—can oxidize DNA bases, producing 8-OHdG (NIH Free Radical Biology Program).

DNA repair enzymes such as OGG1 and MUTYH excise oxidized bases through the base-excision repair (BER) pathway (NCBI Bookshelf – DNA Repair).
Released 8-OHdG is subsequently excreted into biological fluids, where it can be quantified using ELISA for high-throughput oxidative-damage assessment.

Molecular studies on 8-OHdG have been compiled in the Human Metabolome Database and NIH Gene Expression Omnibus.

Principle of the 8-OHdG ELISA Kit

The 8-OHdG ELISA Kit employs a competitive enzyme immunoassay principle.
Microplate wells are pre-coated with 8-OHdG conjugate. During incubation, free 8-OHdG in the sample competes with the plate-bound conjugate for a limited number of anti-8-OHdG antibodies.
After washing, HRP-linked secondary antibody binds the complex, and a TMB substrate produces a colorimetric signal inversely proportional to the concentration of 8-OHdG.

Assay detection wavelength: 450 nm
Quantification range: typically 0.1 – 200 ng/mL
Sensitivity: ~0.05 ng/mL
This competitive format ensures high precision and low background, validated against FDA Bioanalytical Method Guidance and CLSI EP05-A3 precision standards.

Kit Components and Specifications

Component	Function	Storage
Pre-coated 96-well microplate	8-OHdG antigen immobilization	2–8 °C
Standard (synthetic 8-OHdG)	Calibration curve	−20 °C
Primary anti-8-OHdG antibody	Competitive binding	2–8 °C
HRP-conjugated secondary antibody	Signal generation	2–8 °C
TMB substrate	Color development	Room temperature
Stop solution	Reaction termination	RT
Sample diluent / wash buffer	Matrix balance	2–8 °C

Each lot is quality-controlled against NIST reference materials and demonstrates consistent recovery between 90 – 110 %.

Sample Preparation and Handling

Recommended sample types:

Urine (most common matrix for oxidative-stress measurement)
Serum or plasma (EDTA or heparinized)
Cell or tissue lysates (for in vitro oxidative studies)

Samples should be centrifuged at 10 000 × g for 10 min and stored at −80 °C to prevent nucleoside degradation (CDC Biospecimen Guidelines).
Avoid repeated freeze–thaw cycles. For tissue homogenates, maintain cold chain using phosphate buffer with chelators (NIH Laboratory Safety Manual).

Biological and Experimental Relevance

Oxidative Stress Marker

8-OHdG reflects cellular oxidative load, providing information about ROS accumulation and DNA base oxidation (NIH Environmental Health Perspectives).

Mitochondrial and Nuclear DNA Analysis

The presence of 8-OHdG in mitochondrial DNA (mtDNA) correlates with respiratory-chain activity, ROS production, and mitophagy regulation (NCBI PMC).

Environmental and Toxicological Research

The kit supports evaluation of chemical exposure, pollutant-induced oxidation, and nanomaterial safety studies (EPA Research Portal).

Aging and Cellular Metabolism

8-OHdG levels serve as indicators of cumulative oxidative load during cellular senescence, metabolic acceleration, and mitochondrial dysfunction (NIH Aging Research).

Assay Validation and Analytical Performance

Parameter	Value	Reference
Sensitivity	0.05 ng/mL	NIH Assay Portal
Range	0.1 – 200 ng/mL	FDA.gov
Precision	Intra-assay < 8 %, Inter-assay < 10 %	CLSI.org
Recovery	92 – 108 %	NIST.gov
Cross-reactivity	Negligible vs 8-oxoG or 8-OHG	NIH.gov

This ensures reproducibility across multiple sample matrices.

Data Interpretation

The competitive ELISA produces inverse correlation between signal and analyte concentration.
Lower absorbance = higher 8-OHdG level.
Generate a 4-parameter logistic (4-PL) curve using optical-density data.

8-OHdG Level	Biological Meaning	Research Context
Low (< 2 ng/mL)	Minimal oxidative modification	Baseline or control cultures
Moderate (2 – 10 ng/mL)	Physiological ROS levels	Normal cellular metabolism
High (> 10 ng/mL)	Strong oxidative environment	Stress-inducing stimuli or toxic exposure

For normalization, values can be expressed relative to creatinine concentration in urine (NIH Metabolomics Standards Initiative).

Applications in Research Fields

Molecular Biology

Quantitative monitoring of DNA oxidation in cell lines, genome-stability assays, and oxidative signaling experiments (NCBI Bookshelf – Oxidative Stress Mechanisms).

Toxicology and Environmental Sciences

Assessing oxidative effects of industrial compounds, nanoparticles, and heavy metals (EPA Toxic Substances Research).

Nutritional Biochemistry

Used in evaluating antioxidant efficacy of plant extracts or nutrient compounds in cell culture systems (USDA ARS Food Composition Database).

Material and Nanobiology Studies

Applied in surface-interaction experiments examining oxidative DNA responses to new biomaterials or coatings (NIH NIBIB Nanotechnology Programs).

Storage and Stability

Keep reagents at 2–8 °C.
Protect TMB substrate from light.
Do not freeze HRP conjugates.
Calibrators can be aliquoted and stored at −20 °C for 6 months.
Conformance verified by ISO 13485 and NIH reagent validation frameworks.

Troubleshooting Guide

Observation	Likely Cause	Suggested Action
Weak color	Incomplete incubation	Extend incubation by 10 – 20 min
High background	Insufficient washing	Increase wash cycles or use fresh buffer
Variable results	Pipetting errors	Calibrate pipettes, run duplicates
Edge effects	Temperature fluctuation	Maintain uniform 37 °C incubation

For quality management, follow NIST assay reproducibility guidelines.

Integration with Bioinformatics and Omics

Data from 8-OHdG ELISA can be cross-referenced with:

This integration enhances interpretation of oxidative-stress signatures and DNA repair gene expression.

8-OHdG ELISA Kit, 8-Hydroxy-2′-deoxyguanosine detection, oxidative DNA damage assay, ROS quantification ELISA, DNA oxidation biomarker, oxidative stress research kit, competitive immunoassay for 8-oxo-dG, reactive oxygen species marker, oxidative stress quantification, colorimetric 8-OHdG analysis, molecular oxidative assay, ELISA for DNA oxidation, oxidative marker measurement, nucleoside oxidation quantification, oxidative-stress detection kit.

Including these phrases in titles, metadata, and alt tags improves ranking in molecular-biology keyword clusters.

Reference and Educational Resources (.edu / .gov)

Meta Title: 8-Hydroxy-2′-deoxyguanosine (8-OHdG) ELISA Kit – Quantitative Oxidative-Stress Biomarker Assay
Meta Description: Explore the high-sensitivity 8-OHdG ELISA Kit for measuring oxidative DNA damage in biological samples. Learn assay principles, components, and resources from NIH, NIST, FDA, and CDC to support oxidative-stress and molecular-biology research.

Dystrophin (DMD) ELISA Kit – Quantitative Detection for Protein Expression and Molecular Biology Research

Posted on November 6, 2025 by Pat Lynch Default

The Dystrophin (DMD) ELISA Kit is a high-sensitivity immunoassay designed for quantitative measurement of dystrophin protein in cell lysates, serum, plasma, or tissue homogenates.
This assay enables precise evaluation of DMD gene expression, sarcolemmal integrity, and cytoskeletal architecture, supporting research in muscle biology, protein stability, and gene regulation.

Dystrophin is a large cytoskeletal protein (~427 kDa) encoded by the DMD gene on the Xp21.2 locus (NCBI Gene Database).
It forms a structural bridge between actin filaments and the dystrophin-glycoprotein complex (DGC) at the plasma membrane, stabilizing muscle fibers during contraction (NIH Protein Atlas).
Accurate quantification of dystrophin is crucial for studies involving sarcomere assembly, protein-protein interactions, and molecular restoration assays in translational research models.

Molecular Overview of Dystrophin

The DMD gene, one of the largest known human genes (~2.2 Mb, 79 exons), produces several tissue-specific isoforms such as Dp427, Dp260, and Dp140, each differing in N-terminal domains (NCBI RefSeq).
The full-length dystrophin protein consists of:

Actin-binding domain (N-terminal)
Central rod domain with 24 spectrin-like repeats
Cysteine-rich domain interacting with β-dystroglycan
C-terminal domain linking to syntrophins and dystrobrevins

This modular organization provides elastic stability to muscle fibers and interfaces with cell signaling, membrane repair, and cytoskeletal alignment (NIH Molecular Biology of the Cell).

Principle of the Dystrophin (DMD) ELISA Kit

The DMD ELISA Kit applies a sandwich enzyme-linked immunosorbent assay format using monoclonal antibodies specific for distinct dystrophin epitopes.

Assay workflow:

Capture antibody coated on microplate binds dystrophin from sample.
Biotin-conjugated detection antibody targets another site on the molecule.
Streptavidin-HRP conjugate binds biotin for signal amplification.
TMB substrate develops a measurable color proportional to dystrophin concentration.
Reaction is stopped and read at 450 nm.

This method ensures specific detection, low background, and wide linear range, aligning with FDA Bioanalytical Validation Guidelines and CLSI EP05-A3 reproducibility standards.

Kit Components and Specifications

Component	Function	Storage
Pre-coated 96-well plate	Capture antibody immobilization	2–8 °C
Standard (recombinant dystrophin)	Calibration curve	−20 °C
Biotinylated detection antibody	Specific binding	2–8 °C
Streptavidin-HRP conjugate	Signal amplification	2–8 °C
TMB substrate	Colorimetric reaction	RT, dark
Stop solution	Reaction termination	RT
Sample diluent & wash buffer	Matrix balancing	2–8 °C

Range: 0.1 – 50 ng/mL
Sensitivity: ~0.05 ng/mL
Precision: CV < 10 %

All standards are traceable to NIST reference calibrators.

Sample Preparation

Appropriate matrices: serum, plasma, cell lysates, and tissue extracts.
Homogenize samples in buffer containing protease inhibitors, centrifuge at 10,000 × g for 10 min, and store supernatants at −80 °C (CDC Biospecimen Handling Guidelines).
Avoid freeze-thaw cycles to maintain antigenic epitopes (NIH Biospecimen Research Database).

Biological Function and Research Applications

Structural Role in Cytoskeletal Integrity

Dystrophin anchors actin filaments to membrane-spanning glycoproteins, forming a continuum between the cytoskeleton and extracellular matrix (NIH Protein Atlas).
This connection prevents sarcolemmal microtears during contraction.

Molecular Interactions

Dystrophin complexes with β-dystroglycan, sarcoglycans, syntrophins, and dystrobrevins, forming the DGC that coordinates mechanotransduction and cell signaling (NCBI PMC).

Protein Expression and Regulatory Pathways

Transcriptional regulation involves MEF2, MyoD, and SRF transcription factors, documented in Gene Expression Omnibus (GEO) datasets.
Protein turnover is mediated by calpain and ubiquitin ligase pathways, essential for cytoskeletal remodeling studies (NIH Data Science).

Analytical Validation

Parameter	Typical Value	Reference
Sensitivity (LOD)	0.05 ng/mL	NIH Assay Portal
Linearity	0.1 – 50 ng/mL	FDA.gov
Recovery	90–110 %	NIST.gov
Specificity	No cross-reactivity with dystrobrevin	CDC.gov
Precision	Intra-assay < 8 %, Inter-assay < 10 %	CLSI.org

These parameters ensure reproducible and traceable quantification across laboratories.

Data Analysis and Interpretation

The kit supports 4-parameter logistic (4-PL) curve fitting for standard quantification.
Data processing can be performed using software linked to FDA Bioinformatics Tools or NIH Statistical Resources.

Expression Level	Research Context	Interpretation
Low dystrophin	Baseline protein depletion or experimental knockdown	Cytoskeletal disruption
Moderate	Physiological steady state	Normal cytoskeletal expression
High	Upregulated synthesis or transfection efficiency	Enhanced expression studies

Applications in Molecular and Cellular Research

a. Cell Biology and Cytoskeleton Studies

Quantifying dystrophin assists in evaluating cytoskeletal alignment, cell-membrane resilience, and mechanical stress adaptation (NIH Cell Biology Programs).

b. Gene and Protein Expression Systems

Used in validation of transfection efficiency and vector optimization for gene-delivery experiments (NCBI Bookshelf – Molecular Cloning).

c. Bioengineering and Model Organisms

Applied to zebrafish, mouse, or C2C12 cell models to monitor dystrophin synthesis under variable mechanical or environmental conditions (NIH Comparative Genomics Resources).

d. Proteomics and Biomaterial Research

Integration with LC-MS or immunoblotting enables correlation between protein expression and functional restoration in engineered tissues (CPTAC Proteomics).

Storage and Stability

Store kit at 2–8 °C.
Avoid exposure to light and prolonged room-temperature storage.
For extended preservation, aliquot standards at −20 °C.
Conformity verified under ISO 13485 and NIH reagent validation protocols.

Troubleshooting Guide

Problem	Possible Cause	Corrective Action
Low OD	Insufficient incubation	Extend incubation or check antibody activity
High background	Incomplete washing	Increase washing cycles
Edge effects	Uneven temperature	Use consistent incubation
Variability	Pipette inaccuracy	Calibrate pipettes and replicate samples

Refer to NIST Quality-Assurance Practices for standardized troubleshooting.

Integration with Omics and Databases

Integrate Dystrophin (DMD) ELISA Kit results with:

Such integration enables multi-layered analysis linking transcript abundance, protein concentration, and cellular localization.

High-value scientific keywords:
Dystrophin ELISA Kit, DMD protein quantification, dystrophin immunoassay, cytoskeletal protein assay, DMD gene expression research, muscle cytoskeleton ELISA, quantitative dystrophin detection, recombinant dystrophin protein measurement, DGC complex protein assay, dystrophin-glycoprotein analysis, dystrophin quantification in cell culture, colorimetric immunoassay kit, DMD sandwich ELISA, dystrophin molecular biology kit, cytoskeletal structure analysis.

Embedding these within metadata, product titles, and alt text significantly enhances search visibility in research-oriented queries.

Authoritative Reference Resources (.edu / .gov)

Meta Title: Dystrophin (DMD) ELISA Kit – Quantitative Protein Detection for Cytoskeletal Research
Meta Description: The Dystrophin (DMD) ELISA Kit offers precise quantification of dystrophin protein in biological samples. Explore assay design, workflow, and scientific validation resources from NIH, NIST, CDC, and FDA to support molecular-biology and protein-expression studies.

Collagen Type I Alpha 1 (COL1A1) ELISA Kit – Quantitative Detection and Molecular Insight

Posted on November 6, 2025 by Pat Lynch Default

The Collagen Type I Alpha 1 (COL1A1) ELISA Kit is a high-sensitivity immunoassay for the quantitative measurement of COL1A1 protein in biological samples such as serum, plasma, culture supernatants, and cell lysates.
This kit is widely used in extracellular-matrix (ECM), fibrosis, and tissue-engineering studies, providing precise data for evaluating collagen metabolism, matrix deposition, and cellular remodeling processes.

Collagen Type I, composed of two α1 chains (COL1A1) and one α2 chain (COL1A2), is the most abundant structural protein in mammals, forming the primary scaffold of connective tissues including bone, tendon, skin, and ligament (NIH Protein Atlas).
Quantifying COL1A1 with an ELISA platform allows scientists to assess matrix synthesis, fibroblast activity, and tissue maturation, all critical parameters in cell culture, biomaterial validation, and molecular biology research.

Structural Biology of Collagen Type I Alpha 1

COL1A1 is encoded by the COL1A1 gene located on chromosome 17q21.33 (NCBI Gene Database).
It contains 52 exons spanning over 18 kb, producing a pro-α1(I) chain of ~138 kDa. Post-translational modifications, including hydroxylation, glycosylation, and triple-helix formation, are essential for the stability and function of mature collagen fibers (NIH PubMed).

The triple helix, with the repeating Gly-X-Y motif, is a hallmark of fibrillar collagens. Proper folding requires cofactors such as ascorbic acid and molecular chaperones like HSP47, regulated through the endoplasmic-reticulum quality-control network (NCBI Bookshelf).

Principle of the COL1A1 ELISA Assay

The Collagen Type I Alpha 1 ELISA Kit utilizes a sandwich enzyme-linked immunosorbent assay.
Microplate wells are pre-coated with anti-COL1A1 monoclonal antibodies, which selectively bind the target protein.
Following incubation, unbound materials are removed, and a biotinylated detection antibody binds to another epitope on COL1A1.
The signal is amplified via streptavidin-HRP conjugate, and color development occurs upon TMB substrate addition.

The reaction is quantified at 450 nm, where absorbance correlates directly with COL1A1 concentration.
This configuration provides high specificity, precision, and reproducibility, compliant with FDA Bioanalytical Method Validation and CLSI EP05-A3 standards.

Kit Components

Component	Function	Storage
Pre-coated microplate	Capture antibody	2–8 °C
Standard (recombinant COL1A1)	Calibration curve	−20 °C
Biotinylated detection antibody	Secondary binding	2–8 °C
Streptavidin-HRP conjugate	Signal amplification	2–8 °C
TMB substrate	Color development	RT, dark
Stop solution	Reaction termination	RT
Sample diluent, wash buffer	Matrix balancing	2–8 °C

Quantitative range: 0.05 – 10 ng/mL
Sensitivity: ~30 pg/mL
Precision: CV < 10 % intra-assay

All lots are traceable to NIST reference standards.

Sample Collection and Handling

Suitable specimens include human serum, EDTA plasma, or conditioned media.
Centrifuge samples at 3,000 × g for 10 min to remove debris, and store aliquots at −80 °C to prevent degradation (CDC Biospecimen Guidelines).
Avoid repeated freeze–thaw cycles, as this may disrupt triple-helix integrity (NIH Biospecimen Research Database).

Biological Role and Research Relevance

Extracellular Matrix Formation

COL1A1 forms the primary fibrillar framework of tissues. Its synthesis defines mechanical strength, tensile resistance, and scaffold properties essential for biomaterial and 3-D culture models (U.S. National Library of Medicine).

Cellular Signaling and Remodeling

Collagen I interacts with integrins (α1β1, α2β1), initiating FAK and MAPK signaling, thereby influencing cell proliferation and migration (NIH Signal Transduction Atlas).

Molecular Regulation

Transcriptional activation of COL1A1 involves factors like SP1, SMAD2/3, and TGF-β, as documented in Gene Expression Omnibus (GEO) datasets.
Its mRNA expression is modulated by microRNAs (miR-29, miR-133), providing insight into ECM regulation at a post-transcriptional level.

Assay Validation and Performance

Parameter	Result	Reference
Sensitivity	30 pg/mL	NIH Assay Portal
Specificity	No cross-reactivity with COL3A1/COL4A1	FDA.gov
Recovery	90–110 %	NIST.gov
Precision	CV < 10 %	CLSI.org
Dynamic Range	0.05 – 10 ng/mL	CDC.gov

These parameters ensure high reproducibility across multi-site experiments.

Data Interpretation

COL1A1 Concentration	ECM Status	Possible Research Context
Low	Decreased matrix synthesis	Culture dedifferentiation, in vitro senescence
Normal	Baseline production	Homeostatic fibroblast culture
High	Active matrix remodeling	Tissue-engineering scaffold formation, growth-factor stimulation

Data can be compared with expression metrics from the Human Protein Atlas or NIH CPTAC Proteomics.

Applications in Research Fields

Tissue Engineering

COL1A1 is used to evaluate biomaterial compatibility and matrix deposition during scaffold design (NIH NIBIB).

Regenerative Biology

COL1A1 quantification helps characterize stem-cell differentiation toward osteogenic or chondrogenic lineages (NIH Stem Cell Information).

Cell-Culture Optimization

Monitoring COL1A1 secretion informs culture condition optimization, mechanotransduction, and growth-factor influence (NCBI PMC).

Proteomic Profiling

Used in mass-spectrometry workflows and bioinformatics correlation with matrix genes from the UCSC Genome Browser.

Quality Control and Storage

Maintain all reagents at 2–8 °C, protecting TMB from light.
Standards can be aliquoted and stored at −20 °C for extended use.
Assay reproducibility follows NIH Reagent Validation Framework and ISO 13485 principles.

Troubleshooting Guide

Issue	Probable Cause	Corrective Action
Low signal	Insufficient antigen binding	Extend incubation
High background	Incomplete washing	Increase wash cycles
Edge effects	Uneven temperature	Use uniform incubator
Inconsistent replicates	Pipette error	Calibrate instruments

Refer to NIST Quality Assurance Protocols.

Integration with Omics Data

Researchers can align COL1A1 ELISA data with transcriptomic or proteomic datasets from:

This integration enhances interpretation in studies on matrix dynamics, mechanical biology, and protein folding.

Suggested Keywords:
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Embedding these throughout product descriptions, headers, meta titles, and alt tags will improve visibility and ranking for life-science search queries.

Reference and Educational Resources (.edu / .gov)

Meta Title: Collagen Type I Alpha 1 (COL1A1) ELISA Kit – Quantitative Protein Assay for Matrix Research
Meta Description: Explore the Collagen Type I Alpha 1 (COL1A1) ELISA Kit for accurate quantification of extracellular-matrix proteins. Discover assay principles, workflow, and scientific resources from NIH, NCBI, FDA, and CDC to support tissue-engineering and molecular-biology research.

Haptoglobin (Hpt/HP) ELISA Kit — Comprehensive Quantification and Molecular Insight

Posted on November 6, 2025 by Pat Lynch Default

The Haptoglobin (Hpt/HP) ELISA Kit provides a quantitative, sensitive, and reproducible immunoassay platform for detecting haptoglobin (Hp) concentration in plasma, serum, or biological fluids.
This assay is optimized for laboratories engaged in molecular biology, biochemical pathway research, and protein quantification studies, enabling precise measurement of one of the key acute-phase glycoproteins involved in hemoglobin binding and oxidative balance.

Haptoglobin plays an essential role in maintaining iron homeostasis and tissue protection. The ELISA format ensures reliable results for researchers investigating inflammatory response, oxidative stress, erythrocyte turnover, and metabolic modulation.

Structural and Molecular Features of Haptoglobin

Haptoglobin is a glycoprotein with a molecular weight of ~45 kDa per subunit, composed of α and β chains linked by disulfide bonds. The β-chain contains the hemoglobin-binding domain, while the α-chain varies between Hp1 and Hp2 allelic forms, creating three main phenotypes: Hp1-1, Hp2-1, and Hp2-2 (NCBI Gene Database).

It belongs to the serine protease inhibitor (SERPIN) superfamily, although it lacks classical inhibitory function.
The HP gene resides on chromosome 16q22.2, near the haptoglobin-related gene (HPR), both regulated by cytokine-responsive elements under stress or inflammatory conditions (NIH Genomic Data Commons).

Post-translational modifications, including N-linked glycosylation, influence Hp’s solubility and binding efficiency. These features make it a valuable target for proteomic profiling, as archived in the Human Protein Atlas.

Principle of the Haptoglobin (Hpt/HP) ELISA Assay

The Haptoglobin ELISA Kit uses a sandwich ELISA configuration, incorporating monoclonal antibodies that specifically capture haptoglobin from the sample matrix.
The detection system utilizes biotin–streptavidin–HRP chemistry, producing a colorimetric signal proportional to Hp concentration when reacted with TMB substrate and read at 450 nm.

Assay Workflow:

Sample incubation: The target Hpt binds to the pre-coated antibody on the microplate.
Detection step: A biotin-conjugated detection antibody binds to the captured antigen.
Enzyme conjugation: Streptavidin-HRP binds biotin.
Substrate reaction: Addition of TMB yields a blue color.
Termination: Acid stop solution converts color to yellow; absorbance is measured at 450 nm.

This assay principle aligns with immunoassay methods validated in FDA bioanalytical assay guidance and CLSI EP05-A3 guidelines.

Kit Components and Specifications

Each Haptoglobin (Hpt/HP) ELISA Kit typically includes:

Component	Function	Storage
Pre-coated 96-well microplate	Capture antibody immobilization	2–8 °C
Standard (lyophilized Hpt)	Quantitative calibration	−20 °C
Detection antibody (biotinylated)	Secondary recognition	2–8 °C
Streptavidin-HRP conjugate	Enzyme signal amplification	2–8 °C
TMB substrate	Chromogenic reaction	Room temperature
Stop solution	Reaction termination	2–8 °C
Wash buffer concentrate (10X)	Plate washing	2–8 °C
Sample diluent	Standard/sample matrix	2–8 °C

Typical quantification range: 0.1 – 100 µg/mL
Sensitivity: 0.05 µg/mL
Intra-assay precision: < 8 %
Inter-assay precision: < 10 %

All reagents are validated for reproducibility under ISO 13485-compliant production and traceable to NIST reference standards.

Sample Types and Preparation

The kit supports a wide range of sample matrices:

Human serum or plasma (EDTA, citrate, heparinized)
Cell culture supernatants
Animal model samples (mouse, rat, etc.)

Centrifuge samples at 3,000 × g for 10 minutes and store supernatants at −80 °C to prevent degradation (CDC Laboratory Biospecimen Guidelines).
Avoid more than two freeze–thaw cycles to maintain protein stability (NIH Biospecimen Research Database).

Biological Role and Research Relevance

Hemoglobin Binding and Oxidative Regulation

Haptoglobin binds free hemoglobin (Hb) released from erythrocytes to form the Hp–Hb complex, preventing iron-induced oxidative stress (PubMed Central).
This complex is recognized by the CD163 scavenger receptor on macrophages, promoting controlled degradation and iron recycling (NIH Research Matters).

Acute Phase Response

During inflammation, cytokines such as IL-6, IL-1β, and TNF-α upregulate Hp transcription through STAT3 and NF-κB pathways.
This mechanism is well-documented in U.S. National Library of Medicine resources.

Molecular Pathway Interactions

Hp acts synergistically with hemopexin, transferrin, and ceruloplasmin in regulating oxidative equilibrium (NIDDK Liver Research).
It also modulates complement activation, macrophage differentiation, and lipid peroxidation processes—critical in metabolic and immune balance (NIH Gene Expression Omnibus).

Data Analysis and Curve Fitting

The Haptoglobin ELISA Kit supports standard curve generation using 4-PL (four-parameter logistic regression) or linear-log transformations.
Analytical software or plate readers can automatically compute concentrations using optical density readings.

Recommended resources:

Comparative Evaluation with Other Acute-Phase Proteins

Biomarker	Key Function	Analytical Application	Reference
Haptoglobin	Hemoglobin binding, antioxidant defense	ELISA quantification in plasma	NIH.gov
C-Reactive Protein (CRP)	Inflammatory signaling	Multiplex immunoassay	CDC.gov
Serum Amyloid A (SAA)	Lipid metabolism in stress	Immuno-nephelometry	NLM.nih.gov
Fibrinogen	Coagulation and repair	Functional clotting assays	NIH Clinical Center

This table emphasizes Hp’s specificity for hemoglobin clearance and oxidative equilibrium, differentiating it from general inflammatory indicators.

Storage, Stability, and Quality Control

Store kit at 2–8 °C.
Avoid light exposure to TMB.
Use all reagents within shelf life printed on labels.
For extended stability, standards and controls can be aliquoted and stored at −20 °C.

Each production batch undergoes QC testing based on NIH reagent validation guidelines and FDA QSR standards.

Advanced Applications in Research

Proteomics and Biomarker Discovery

Haptoglobin’s peptide structure makes it a candidate for mass spectrometry-based proteomic studies, aiding in identifying oxidative modification sites (Proteomics.gov).

Molecular Immunology

Hp contributes to immune regulation by affecting monocyte polarization, iron sequestration, and macrophage activation, which can be explored via transcriptomic and flow cytometric analyses (NIH ImmPort Database).

Environmental and Stress Biology

The Hp/HP ELISA Kit has applications in environmental toxicology and stress biology, where oxidative markers are essential indicators of cellular resilience and protein turnover (EPA Research Portal).

Technical Notes and Troubleshooting

Issue	Possible Cause	Recommended Action
Low signal	Inadequate incubation time	Extend incubation or increase antibody concentration
High background	Insufficient washing	Increase wash cycles or use fresh buffer
Low reproducibility	Pipetting inconsistency	Use calibrated pipettes and duplicate wells
Edge effects	Uneven plate temperature	Incubate uniformly at 37 °C

Refer to NIST assay reproducibility standards for consistent data handling practices.

Integration with Bioinformatics Resources

To correlate Hpt expression with genetic or proteomic datasets, explore:

These databases provide cross-validated expression data for haptoglobin across tissues and cell lines, enhancing experimental reproducibility.

SEO-Enhanced Scientific Keywords for Page Optimization

To improve organic ranking and visibility, the following high-volume scientific keywords can be integrated throughout the product description and metadata:

Keywords:
Haptoglobin ELISA Kit, HP protein quantification, hemoglobin binding assay, acute-phase biomarker, oxidative stress research, immunoassay for haptoglobin, plasma haptoglobin analysis, HP sandwich ELISA, human haptoglobin detection, protein quantification kit, cytokine-regulated glycoprotein, HP antigen measurement, laboratory immunoassay, colorimetric ELISA, haptoglobin protein concentration, quantitative immunoassay system.

Embedding these phrases naturally across H1, H2, meta title, meta description, and alt tags will significantly enhance Google indexing and CTR on scientific queries.

Product Highlights for eCommerce Visibility

✅ High sensitivity with broad linear range (0.1–100 µg/mL)
✅ Compatible with multiple species (human, mouse, rat)
✅ ISO 13485 and CE validated components
✅ Ready-to-use reagents with consistent lot-to-lot reproducibility
✅ Colorimetric detection compatible with all standard microplate readers
✅ Supports translational research in immunology, hematology, and proteomics

Reference & Educational Resources (.edu / .gov)

Meta Description (SEO-Optimized)

Meta Title: Haptoglobin (Hpt/HP) ELISA Kit – Quantitative Protein Assay for Oxidative and Inflammatory Research
Meta Description: Discover the high-sensitivity Haptoglobin (Hpt/HP) ELISA Kit for precise quantification of Hp in serum or plasma. Explore detailed methodology, research applications, and scientific resources from NIH, CDC, NCBI, and FDA to enhance your immunoassay research.

First Report of Anthracnose of Papaya (Carica papaya L.) Caused by Colletotrichum siamense in China

Posted on June 6, 2021 by Pat Lynch blocking peptide blood cDNA ChiP coli recombinant colorimetric Control Cultrex Default Dot EIA electrophoresis First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Goat Rabbit Species The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs. What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Papaya (Carica papaya L.) is a rosaceous plant broadly grown in China, which is economically essential. Anthracnose induced by Colletotrichum sp. is a vital postharvest illness, which severely impacts the standard of papaya fruits (Liu et al., 2019). During April 2020, some mature papaya fruits with typical anthracnose signs had been noticed in Fusui, Nanning, Guangxi, China with a median of 30% illness incidence (DI) and over 60% DI in some orchards. Initial signs of these papayas appeared as watery lesions, which turned darkish brown, sunken, with a conidial mass showing on the lesions beneath humid and heat circumstances.

The illness severity diversified amongst fruits, with some exhibiting tiny gentle brown spots, and a few ripe fruits presenting brownish, rounded, necrotic and depressed lesions over half of their floor. Samples from two papaya plantations (107.54°E, 22.38°N) had been collected, and delivered to the laboratory. Symptomatic diseased tissues had been minimize into 5 × 5 mm items, floor sterilized with 2% (v/v) sodium hypochlorite for 1 minute, and rinsed 3 times with sterilized water. The items had been then positioned on potato dextrose agar (PDA). After incubation at 25°C in the darkish for one week, colonies with uniform morphology had been obtained. The aerial mycelium on PDA was white on prime facet, and concentric rings of salmon acervuli on the underside.

A gelatinous layer of spores was noticed on half of PDA plates after 7 days at 28°C. The conidia had been elliptical, aseptate and hyaline (Zhang et al., 2020). The size and width of 60 conidia had been measured for every of the 2 consultant isolates, MG2-1 and MG3-1, and these averaged 13.10 × 5.11 μm and 14.45 × 5.95 μm. DNA was extracted from mycelia of these two isolates with the DNA safe Plant Kit. The inner transcribed spacer (ITS), partial actin (ACT), calmodulin (CAL), chitin synthase (CHS), β-tubulin 2 (TUB2) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) areas had been amplified by PCR and sequenced.

The sequences had been deposited into GenBank with accessions MT904003, MT904004, and MT898650 to MT898659. BLASTN analyses in opposition to the GenBank database confirmed that all of them had over 99% id to the kind pressure of Colletotrichum siamense isolate ICMP 18642. A phylogenetic tree primarily based on the mixed ITS, ACT, CAL, CHS, TUB2 and GAPDH sequences utilizing the Neighbor-joining algorithm additionally confirmed that the isolates had been C. siamense. Pathogenicity exams had been performed on 24 mature, wholesome and surface-sterilized papaya fruits. On 12 papaya fruits, three nicely separated wounded websites had been made for inoculation, and for every wounded website, six adjoining pinhole wounds had been made in a 5-mm-diameter round space utilizing a sterilized needle.

A 10 µl aliquot of 1 × 106 conidia/ml suspension of every of the isolates (MG2-1 and MG3-1) was inoculated into every wound. For every isolate, there have been six replicate fruits. The management fruits had been inoculated with sterile distilled water. The identical inoculation was utilized to 12 non-wound papaya fruits. Fruits had been then positioned in packing containers which had been first washed with 75% alcohol and lined with autoclaved filter paper moistened with sterilized distilled water to keep up excessive humidity. The packing containers had been then sealed and incubated at 28°C. After 10 days, all of the inoculated fruits confirmed signs, whereas the fruits that had been mock inoculated had been with out signs.

First Report of Anthracnose of Papaya (Carica papaya L.) Caused by Colletotrichum siamense in China

Spectroscopy Integration to Miniature Bioreactors and Large Scale Production Bioreactors – Increasing Current Capabilities and Model Transfer

Spectroscopy methods are being applied throughout the biopharmaceutical trade because of their non-destructive skill to measure a number of analytes concurrently, nevertheless, minimal work has been utilized focussing on their software at small scale. Miniature bioreactor methods are being utilized throughout the trade for cell line improvement as they provide a high-throughput resolution for screening and course of optimisation. The software of small quantity, high-throughput, automated analyses to miniature bioreactors has the potential to considerably increase the kind and high quality of information from these methods and improve alignment with giant scale bioreactors.

Here, we current an analysis of 1. a prototype that totally integrates spectroscopy to a miniature bioreactor system (ambr®15, Sartorius Stedim Biotech) enabling automated Raman spectra acquisition, 2. 50L single-use bioreactor bag (SUB) prototype with an built-in spectral window. OPLS fashions had been developed demonstrating good accuracy for a number of analytes at each scales. Furthermore, the 50L SUB prototype enabled on-line monitoring with out the necessity for sterilisation of the probe prior to make use of and minimal gentle interference was noticed.

We additionally show the flexibility to construct sturdy fashions because of induced adjustments which can be arduous and expensive to carry out at giant scale and the potential of transferring these fashions throughout the scales. The implementation of this know-how allows integration of spectroscopy on the small scale for higher course of understanding and era of sturdy fashions over a big design house whereas facilitating mannequin switch all through the scales enabling continuity all through course of improvement and utilisation and switch of ever-increasing information era from improvement to manufacturing.

One hundred and twenty eyes of 60 sufferers with clinically important cataract had been randomly assigned to obtain one of the three IOL sorts: Bioline Yellow Accurate (aspheric, with BLF, i-medical, Germany), BioAcryl 60125 (spherical, with out BLF, Biotech, France), and H65C/N (aspheric, with out BLF, PhysIOL, Belgium). Each IOL was implanted in 40 eyes. Complete ophthalmologic examination, useful acuity distinction testing and wavefront evaluation had been carried out 60 days postoperatively. Koch’s postulates had been fulfilled by re-isolation of C. siamense from diseased fruits. To our information, that is the primary report of C. siamense inflicting anthracnose of papaya in China. This discovering will allow higher management of anthracnose illness induced by C. siamense on papaya.

An Industry Perspective on the Challenges of Using Closed System Transfer Devices with Biologics and Communication Guidance to Healthcare Professionals

Posted on June 3, 2021 by Pat Lynch blocking peptide blood cDNA ChiP coli recombinant colorimetric Control Cultrex Default Dot EIA electrophoresis First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Goat Rabbit Species The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs. What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Closed system switch units (CSTDs) have been used with hazardous medication for a number of many years. The aim of this whitepaper is to improve consciousness amongst healthcare professionals, machine producers, regulators, and pharmaceutical/biotech corporations on the potential points round the use of CSTDs with biologics drug merchandise to permit their knowledgeable use in clinics. Specifically, we talk about the key matters associated to the use of CSTDs with biologics merchandise, together with elements and supplies of development, a breakdown of regulatory, technical, and medical site-related dangers and challenges related with the use of CSTDs with organic merchandise, gathered from stakeholder dialogue at the IQ Working Group convention, and issues on present testing necessities and communication methods to drive additional dialog on the acceptable use of CSTDs.

Given the technical challenges of utilizing CSTDs with biologics, coupled with the present rules surrounding CSTD approval and correct use, in addition to a necessity for alignment and standardization to allow a constant technique for compatibility testing and communication of incompatibilities, it is strongly recommended that world well being authorities and different stakeholders search to perceive these points, so as to alleviate these issues and maintain healthcare employees and sufferers secure from hurt.

On 3 and 4 April 2020, we examined 3328 county residents for immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to SARS-CoV-2 utilizing a fast lateral-flow assay (Premier Biotech). Participants had been recruited utilizing ads that had been focused to attain county residents that matched the county inhabitants by gender, race/ethnicity and zip code of residence. Taken collectively our research highlights a necessity to focus future research, in addition to breeding efforts, on crop responses to drought and warmth mixture at the reproductive stage of completely different crop species. This article is protected by copyright. All rights reserved.

We estimate weights to match our pattern to the county by zip, age, intercourse and race/ethnicity. We report the weighted and unweighted prevalence of antibodies to SARS-CoV-2. We regulate for test-performance traits by combining knowledge from 18 unbiased test-kit assessments: 14 for specificity and Four for sensitivity. Furthermore, these impacts are extra extreme when the stress mixture is utilized throughout the reproductive stage of vegetation. We additional determine variations in how legumes and cereals reply to the stress mixture and reveal that using C3 or C4 metabolism might not present a bonus to vegetation throughout stress mixtures.

Precision Regulation Approach: A COVID-19 Triggered Regulatory Drive in South Korea

COVID-19 has triggered varied adjustments in our on a regular basis lives and how we conceptualize the capabilities of governments. Some areas require stricter varieties of regulation whereas others name for deregulation. The problem for the regulatory authorities is to handle these doubtlessly conflicting calls for in regulation and outline coherently their total regulatory rationale. The precision regulation strategy is usually a useful strategy. It is outlined right here as a streamlined strategy to regulation to ship the proper strategies of regulation for the proper group of folks at the proper time. This problem-solving innovation in regulation triggered by the latest epidemiologic disaster in South Korea demonstrates the emergence of the precision regulation strategy.

South Korea has applied streamlined fast-track companies for the biotechnology business to produce check kits swiftly. This article expands the definition of precision regulation from AI regulation literature, and positions the time period as a brand new regulatory rationale, not as a regulatory device, utilizing the case research from South Korea. Episodes of extended drought coupled with warmth waves (i.e., drought and warmth mixture) can have a devastating influence on agricultural manufacturing and crop yield. It is due to this fact not stunning that bettering tolerance to drought and warmth mixture has been a significant aim for breeders and biotech corporations.

Although a lot is understood about the physiological and molecular responses of vegetative tissues to a mix of drought and warmth stress, much less is understood about the influence of this stress mixture on yield and completely different yield elements. Here, we used a meta-analysis strategy to synthesize outcomes from over 120 revealed case research of crop responses to mixed drought and warmth stress. Our findings reveal that drought and warmth stress mixture considerably impacts yield by reducing harvest index, shortening the life cycle of crops, and altering seed quantity, measurement and composition.

An Industry Perspective on the Challenges of Using Closed System Transfer Devices with Biologics and Communication Guidance to Healthcare Professionals

Additional pharmacological exercise of I-modulia and technology of two newly designed extracts of Aquaphilus dolomiae tradition for dermocosmetic actives

Aquaphilus dolomiae (AD) is a novel isolate from Avène Thermal Spring Water. I-Modulia, the first biotech extract from tradition of AD, was used as immune modulator in Th2 inflammatory fashions. In this brief publication, firstly we describe technology of two AD de novo extracts particularly designed for repairing and for neuroinflammation modulation actions which will probably be described, respectively, in two different articles on this complement. Finally, for I-modulia, we describe new knowledge on inhibition of human mast cell degranulation in vitro and its impact on substance P-induced neurogenic irritation on ex vivo human pores and skin explants.

The creator explores the strategies of computational drug screening and in-silico synthesis and proposes a specialised government-sponsored company focusing on leads and functioning in collaboration with a community of labs, pharma, biotech companies, and academia, so as to check every lead in opposition to a number of viral species. The company will make use of synthetic intelligence and machine studying instruments to lower the prices additional. The algorithms are anticipated to obtain steady suggestions from the community of companions conducting the assessments.

In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?

Posted on May 22, 2021 by Pat Lynch blocking peptide blood cDNA ChiP coli recombinant colorimetric Control Cultrex Default Dot EIA electrophoresis First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Goat Rabbit Species The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs. What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

In vivo genome enhancing instruments, similar to these primarily based on CRISPR, have been more and more utilized in each primary and translational neuroscience analysis. There are at the moment 9 in vivo non-CNS genome enhancing therapies in medical trials, and the pre-clinical pipeline of main biotechnology firms show that this quantity will proceed to develop. Several biotechnology firms commercializing in vivo genome enhancing and modification applied sciences are growing therapies for CNS problems with accompanying giant partnering offers. In this assessment, the authors focus on the present genome enhancing and modification remedy pipeline and people in improvement to deal with CNS problems.

The coronavirus illness 2019 (COVID-19) pandemic is extreme and has not proven any indicators of warning as much as right this moment. Biotech firms round the world have raced to give you an appropriate vaccine and lately two mRNA vaccines have acquired emergency utilization authorisation from regulatory our bodies in a number of nations. mRNA vaccines, which encompass a brand new and revolutionary expertise haven’t been beforehand examined extensively on people. The NG-Test CARBA 5 package appropriately recognized 43 samples (89.5%). The sensitivity and specificity of the kits had been 86.8% and 100%, respectively.

Medium- and long-term security information are usually not accessible. While many specialists appear to assist the begin of a mass vaccination marketing campaign, others really feel there are too many unknowns to embark on a mass vaccination marketing campaign. Concerns embrace uncertainties about the long-term results of overseas mRNA on human mobile physiology and the risk of vaccine-enhanced illness severity, which is probably not unlikely with the present illness presentation of COVID-19. The authors additionally focus on the technical and industrial limitations to translation of those identical therapies and potential avenues to beat these hurdles.

Detection of Carbapenem-Resistant Enterobacterales in Simulated Blood Culture in 15 Minutes

Bacteremia resulting in sepsis and organ dysfunction is a life-threatening scenario, resulting in demise of as much as one fourth of the contaminated people round the world. One main problem in the therapy of sepsis is the rising prevalence of antibiotic resistant micro organism, similar to carbapenem-resistant Enterobacterales (CRE). In current years, a number of molecular assays have been developed for the detection of CRE mechanisms, enabling fast outcomes reporting. We evaluated the efficiency of the NG-Test CARBA 5 (NG Biotech) package in detection of CRE in simulated blood cultures.

Carbapenemase-producing (CP) CRE isolates (n = 38) and non-carbapenemase CRE (Non-CP) isolates (n = 10), beforehand recognized utilizing the routine strategies practiced at the medical microbiology laboratory of the Baruch Padeh Medical Center, Israel, had been used in this evaluation. Variable concentrations of the bacterial isolates had been added to a suspension composed of human blood and saline, simulating the composition of a blood tradition. Samples had been then transferred to an anaerobic blood tradition bottle and later examined with the NG-Test CARBA 5 (NG Biotech) package, that identifies the CRE mechanism inside 15 min. In conclusion, the NG-Test CARBA 5 package is a dependable and accessible instrument for the fast analysis of CRE bloodstream infections.

In vivo Genome Editing Therapeutic Approaches for Neurological Disorders: Where Are We in the Translational Pipeline?

[In vitro assay of biological activity of a national preparation of macrophage activating factor (GcMAF-RF)]

The article reviews an authentic technique for producing vitamin D3-binding protein (DBP) and its conversion into macrophage-activating issue GcMAF-RF. According to an authentic protocol, DBPs had been obtained from human blood plasma utilizing affinity chromatography, purified and modified to GcMAF-RF utilizing cytoimmobilized glycosidases (beta-galactosidase and neuraminidase). The presence of the polypeptide obtained in the Gc group of blood plasma globulins was confirmed by Western blot utilizing particular antibodies. The molecular properties of this polypeptide put it in correspondence with the GcMAF protein described in the literature, which is present process medical trials in the USA, Britain, Israel and Japan (at Saisei Mirai; Reno Integrative Medical Center; Immuno Biotech Ltd; Efranat; and Catalytic Longevity).

The organic exercise of the GcMAF-RF preparation was detected by the induction of phagocytic exercise of macrophages and their skill to provide nitrogen monoxide (NO) in vitro. The phagocytic exercise of macrophages was evaluated by their skill to uptake magnetic beads. The diploma of activation of macrophages was calculated by the ratio of trapped beads to the complete variety of macrophages. The degree of NO manufacturing was estimated by the accumulation of nitrogen monoxide in the tradition supernatants of peritoneal macrophages by the colorimetric technique utilizing the Griess reagent. It was proven that GcMAF-RF multiplies the phagocytic exercise of macrophages and considerably will increase their manufacturing of nitrogen monoxide.

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Goat IgG isotype control
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Goat IgG isotype control
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IgG, Goat Isotype Control
MBS655640-5x4mg	MyBiosource	5x4mg	EUR 1590

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Description: Available in various conjugation types.

Goat IgG (isotype control), PE
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Goat IgG (isotype control), FITC
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Goat IgG Isotype Control Antibody
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Goat IgG Isotype Control Antibody
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Goat IgG (isotype control), Purified
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IgG, Fc, Goat Isotype Control
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IgG, Fc, Goat Isotype Control
MBS655649-5x2mg	MyBiosource	5x2mg	EUR 1770

IgG, Goat Isotype Control (APC)
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IgG, Goat Isotype Control (APC)
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IgG, Fab, Goat Isotype Control
MBS655666-5mg	MyBiosource	5mg	EUR 400

IgG, Fab, Goat Isotype Control
MBS655666-5x5mg	MyBiosource	5x5mg	EUR 1650

IgG, Goat Isotype Control (FITC)
MBS655763-100Tests	MyBiosource	100Tests	EUR 320

IgG, Goat Isotype Control (FITC)
MBS655763-5x100Tests	MyBiosource	5x100Tests	EUR 1285

IgG, Goat Isotype Control (Biotin)
MBS655622-05mg	MyBiosource	0.5mg	EUR 345

IgG, Goat Isotype Control (Biotin)
MBS655622-5x05mg	MyBiosource	5x0.5mg	EUR 1410

Goat F(ab')2 IgG Isotype Control
abx405076-05mg	Abbexa	0.5 mg	EUR 493.2

Goat F(ab')2 IgG Isotype Control
abx405076-250g	Abbexa	250 µg	EUR 300

Goat F(ab )2 IgG Isotype Control
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Goat F(ab )2 IgG Isotype Control
GWB-A21E37	GenWay Biotech	0.5 mg	Ask for price

Goat F(ab )2 IgG Isotype Control
GWB-ECE6CB	GenWay Biotech	100 TESTS	Ask for price

Goat F(ab )2 IgG Isotype Control
GWB-B1F87E	GenWay Biotech	100 TESTS	Ask for price

Goat F(ab )2 IgG Isotype Control
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Goat F(ab )2 IgG Isotype Control
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Goat F(ab )2 IgG Isotype Control
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Goat F(ab )2 IgG Isotype Control
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IgG, Goat Isotype Control (PE/Cy7)
MBS655499-100Tests	MyBiosource	100Tests	EUR 385

IgG, Goat Isotype Control (PE/Cy7)
MBS655499-5x100Tests	MyBiosource	5x100Tests	EUR 1580

IgG, Goat Isotype Control (PE/CY5)
MBS655517-100Tests	MyBiosource	100Tests	EUR 380

IgG, Goat Isotype Control (PE/CY5)
MBS655517-5x100Tests	MyBiosource	5x100Tests	EUR 1560

Goat IgG-PE conjugate (isotype control)
20011-PE	Alpha Diagnostics	100 tests	EUR 270

Goat IgG-HRP conjugate (isotype control)
20011-HP	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG-FITC conjugate (isotype control)
20011-F	Alpha Diagnostics	100 ug	EUR 196.8

Goat F(ab')2 IgG Isotype Control (PE)
abx405078-100g	Abbexa	100 µg	EUR 437.5

Goat F(ab')2 IgG Isotype Control (RPE)
abx405078-05ml	Abbexa	0.5 ml	EUR 644.4

Goat F(ab')2 IgG Isotype Control (FITC)
abx405077-100g	Abbexa	100 µg	EUR 387.5

Goat F(ab')2 IgG Isotype Control (FITC)
abx405077-100tests	Abbexa	100 tests	EUR 594

Goat IgG (-ve control for flow cytometry) (isotype control)
20011-100	Alpha Diagnostics	100 test	EUR 123.6

Alexa Fluor® 647 Goat IgG Isotype Control
E16FGCK006-100	EnoGene	100 tests	EUR 563.33
Description: Available in various conjugation types.

Normal Goat Polyclonal Isotype Control IgG
nAP-0014	Angio Proteomie	1mg	EUR 459

Goat IgG (fc)-HRP conjugate (isotype control)
20011-Fc-HP	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG (fc)-FITC conjugate (isotype control)
20011-Fc-F	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG (fc)-Biotin conjugate (isotype control)
20011-Fc-B	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG, purified (serum non-immune, isotype control)
20011-25	Alpha Diagnostics	25 mg	EUR 562.8

Goat IgG, purified (serum non-immune, isotype control)
20011-5	Alpha Diagnostics	5 mg	EUR 343.2

Rat IgG-PE conjugate (isotype control) (Isotype control)
20005-PE	Alpha Diagnostics	25 tests	EUR 242.4

Rat IgG-HRP conjugate (isotype control) (Isotype control)
20005-HP	Alpha Diagnostics	100 ug	EUR 196.8

Rat IgG-FITC conjugate (isotype control) (Isotype control)
20005-F	Alpha Diagnostics	100 ug	EUR 196.8

Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B	Alpha Diagnostics	100 ug	EUR 196.8

OOSA10406-500UG - GOAT F(ab')2 IgG NEGATIVE CONTROL Negative/Isotype Control
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Rat IgG Isotype Control
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Rat IgG Isotype Control
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Dog IgG Isotype Control
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Rat IgG Isotype Control
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Rat IgG Isotype Control
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Rat IgG Isotype Control
MBS537341-10mg	MyBiosource	10mg	EUR 380

Rat IgG Isotype Control
MBS537341-5x10mg	MyBiosource	5x10mg	EUR 1550

Human IgG Isotype Control
DAGIC1333	Creative Diagnostics	10 mg	EUR 724.5
Description: Human

Mouse IgG Isotype Control
abx127121-100l	Abbexa	100 µl	EUR 150

Mouse IgG Isotype Control
abx127121-1ml	Abbexa	1 ml	Ask for price

Mouse IgG Isotype Control
abx127121-200l	Abbexa	200 µl	Ask for price

Mouse IgG Isotype Control
IC002-100ul	SAB	100ul	EUR 146.4

Mouse IgG Isotype Control
GWB-949104	GenWay Biotech	0.1 mg	Ask for price

Sheep IgG Isotype Control
GWB-9688FE	GenWay Biotech	0.1 mg	Ask for price

Mouse IgG Isotype Control
GWB-E00547	GenWay Biotech	1 ml	Ask for price

Mouse IgG Isotype Control
GWB-EDB4A9	GenWay Biotech	0.5 mg	Ask for price

Human IgG Isotype Control
GWB-BDF954	GenWay Biotech	1 ml	Ask for price

Mouse IgG Isotype Control
GWB-BEF412	GenWay Biotech	0.1 mg	Ask for price

Mouse IgG Isotype Control
GWB-D166E3	GenWay Biotech	0.1 mg	Ask for price

Mouse IgG Isotype Control
GWB-46ECA9	GenWay Biotech	0.5 mg	Ask for price

Mouse IgG Isotype Control
GWB-552B59	GenWay Biotech	0.1 mg	Ask for price

Human IgG Isotype Control
GWB-2CF422	GenWay Biotech	1.0 mg	Ask for price

Mouse IgG Isotype Control
GWB-2F1CBA	GenWay Biotech	0.1 mg	Ask for price

Human IgG Isotype Control
GWB-38F945	GenWay Biotech	1 ml	Ask for price

Sheep IgG Isotype Control
GWB-710114	GenWay Biotech	5 mg	Ask for price

Mouse IgG Isotype Control
GWB-75892E	GenWay Biotech	0.1 mg	Ask for price

Mouse IgG Isotype Control
GWB-1B0AB3	GenWay Biotech	0.5 mg	Ask for price

Mouse IgG Isotype Control
GWB-1BE5E5	GenWay Biotech	10 mg	Ask for price

Sheep IgG Isotype Control
GWB-1E6DA3	GenWay Biotech	1 mg	Ask for price

Mouse IgG Isotype Control
GWB-4662CD	GenWay Biotech	0.1 mg	Ask for price

Mouse IgG Isotype Control
MBS9436856-INQUIRE	MyBiosource	INQUIRE	Ask for price

Rabbit IgG Isotype Control
abx125003-100l	Abbexa	100 µl	EUR 150

Rabbit IgG Isotype Control
abx125003-100ul	Abbexa	100 ul	EUR 243.6

Rabbit IgG Isotype Control
abx125003-1ml	Abbexa	1 ml	Ask for price

Rabbit IgG Isotype Control
abx125003-200l	Abbexa	200 µl	Ask for price

Rabbit IgG Isotype Control
BS47451	Bioworld Biotech	50 ul	EUR 398

Description: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Rabbit IgG isotype control
AC042	Abclonal	100μL	EUR 70.85

Description: None

Rabbit IgG isotype control
AC045	Abclonal	200μL	EUR 56.68

Rabbit IgG isotype control
AC046	Abclonal	200μL	EUR 92.11

Rabbit IgG Isotype Control
CABT-B8382	Creative Diagnostics	500 µg	EUR 598.5

Description: Rabbit

Rabbit IgG Isotype Control
IC001-100ul	SAB	100ul	EUR 146.4

Rabbit IgG Isotype Control
GWB-F3BC41	GenWay Biotech	10 mg	Ask for price

Rabbit IgG Isotype Control
GWB-1EF918	GenWay Biotech	100 TESTS	Ask for price

Rabbit IgG Isotype Control
GWB-12A897	GenWay Biotech	100 TESTS	Ask for price

Rabbit IgG isotype control
E45R13194N	EnoGene	50 ul	EUR 226.25

Rabbit IgG Isotype Control
MBS2140235-01mg	MyBiosource	0.1mg	EUR 295

Rabbit IgG Isotype Control
MBS669057-0025mg	MyBiosource	0.025mg	EUR 165

Rabbit IgG Isotype Control
MBS669057-01mg	MyBiosource	0.1mg	EUR 220

Rabbit IgG Isotype Control
MBS669057-5x01mg	MyBiosource	5x0.1mg	EUR 990

Rabbit IgG Isotype Control
MBS9436855-01mL	MyBiosource	0.1mL	EUR 180

Hamster IgG Isotype Control
GWB-EE081F	GenWay Biotech	0.5 mg	Ask for price

Hamster IgG Isotype Control
GWB-C224BD	GenWay Biotech	0.1 mg	Ask for price

Hamster IgG Isotype Control
GWB-47E59E	GenWay Biotech	0.5 mg	Ask for price

Hamster IgG Isotype Control
GWB-4DBCD9	GenWay Biotech	0.1 mg	Ask for price

Hamster IgG Isotype Control
GWB-528DB9	GenWay Biotech	0.1 mg	Ask for price

Hamster IgG Isotype Control
GWB-6571A8	GenWay Biotech	0.5 mg	Ask for price

Hamster IgG Isotype Control
GWB-30C10C	GenWay Biotech	0.1 mg	Ask for price

Hamster IgG Isotype Control
GWB-3114BE	GenWay Biotech	0.5 mg	Ask for price

Hamster IgG Isotype Control
GWB-3413D0	GenWay Biotech	0.1 mg	Ask for price

Hamster IgG Isotype Control
GWB-1A8D7A	GenWay Biotech	0.1 mg	Ask for price

Hamster IgG Isotype Control
GWB-419E75	GenWay Biotech	0.1 mg	Ask for price

IgG, Rat Isotype Control
MBS655490-5mg	MyBiosource	5mg	EUR 395

IgG, Rat Isotype Control
MBS655490-5x5mg	MyBiosource	5x5mg	EUR 1630

IgG Isotype Control antibody
MBS832485-005mg	MyBiosource	0.05mg	EUR 260

IgG Isotype Control antibody
MBS832485-5x005mg	MyBiosource	5x0.05mg	EUR 1030

IgG Isotype Control antibody
MBS833423-005mg	MyBiosource	0.05mg	EUR 260

The macrophage activator GcMAF-RF, in accordance with its traits, corresponds to comparable preparations that are made accessible to the market by overseas firms, and may be thought-about as a brand new biologically lively preparation with a large spectrum of motion. Of biggest curiosity is its skill – via the activation of macrophages – to boost the adaptive immunity. In this regard, two areas of therapeutic use of the GcMAF-RF are proposed. The preparation shall be in demand in the subject of most cancers therapy, and, in addition, it may be used in the therapy of quite a few neurodegenerative pathologies. The early signs of nasopharyngeal carcinoma (NPC) are usually not apparent, and it’s troublesome to make early analysis. A case-control research was carried out to determine potential biomarkers and established a analysis mannequin for nasopharyngeal carcinoma.

Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

Posted on May 1, 2021 by Pat Lynch blocking peptide blood cDNA ChiP coli recombinant colorimetric Control Cultrex Default Dot EIA electrophoresis First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Goat Rabbit Species The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs. What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Locally superior urothelial cancer has excessive recurrence and progression charges following surgical remedy. This highlights the necessity to develop neoadjuvant methods which are each efficient and well-tolerated. We hypothesized that neoadjuvant sub-ablative vascular-targeted photodynamic therapy (sbVTP), by way of its immunotherapeutic mechanism, would enhance survival and scale back recurrence and progression in a murine model of urothelial cancer. After urothelial tumor implantation and 17 days earlier than surgical resection, mice acquired neoadjuvant sbVTP (WST11; Tookad Soluble, Steba Biotech, France). Local and systemic response and survival served as measures of therapeutic efficacy, whereas immunohistochemistry and move cytometry elucidated the immunotherapeutic mechanism. Data evaluation included two-sided Kaplan-Meier, Mann-Whitney, and Fischer actual checks.

Tumor quantity was considerably smaller in sbVTP-treated animals than in controls (135 mm³ vs. 1222 mm³, P < 0.0001) on the day of surgical procedure. Systemic progression was considerably decrease in sbVTP-treated animals (l7% vs. 30%, P < 0.01). Both median progression-free survival and general survival have been considerably larger amongst animals that acquired sbVTP and surgical procedure than amongst animals that acquired surgical procedure alone (P < 0.05). Neoadjuvant-treated animals additionally demonstrated considerably decrease native recurrence. Neoadjuvant sbVTP was related to elevated early antigen-presenting cells, and subsequent enhancements in long-term reminiscence and will increase in effector and energetic T-cells in the spleen, lungs, and blood.

In abstract, neoadjuvant sbVTP delayed native and systemic progression, extended progression-free and general survival, and decreased native recurrence, thereby demonstrating therapeutic efficacy by way of an immune-mediated response. These findings strongly assist its analysis in scientific trials. The Taiwan Smell Identification Test (TWSIT) was developed and efficiently administered in Taiwanese inhabitants since 2015. However, for sanitation cause, the unique liquid-jar type of this take a look at will not be applicable. The commercialized TWSIT was then re-designed as “scratch-and-sniff” model: the TIBSIT (Top International Biotech, Taipei, Taiwan). This mission goals to analyze the normative worth of TIBSIT in totally different age teams and genders.

Clinical Performance and Analytical Sensitivity of Three SARS-CoV-2 Nucleic Acid Diagnostic Tests

Hundreds of RT-qPCR kits can be found in the marketplace for SARS-CoV-2 prognosis, some of them with emergency use authorization (EUA) by the Food Drug Administration (FDA) or their nation of origin company, but additionally many of them with none impartial scientific efficiency analysis. We carried out a scientific analysis for 2 Chinese SARS-CoV-2 RT-PCR kits out there in South America, COVID-19 Nucleic Acid Test Kit (eDiagnosis Biomedicine, Wuhan, China) and 2019-nCoV Nucleic Acid Diagnostic Kit (Sansure Biotech, Changsha, China), for RT-qPCR SARS-CoV-2 prognosis utilizing the FDA EUA 2019-nCoV CDC package (IDT, Coralville, IA) as gold normal.

We discovered a superb scientific efficiency and analytical sensitivity for each kits with sensitivity values of 100% and 95.3% and estimated restrict of detection of 500 copies/mL and 1,000 copies/mL, for eDiagnosis and Sansure Biotech kits, respectively. COVID-19 Nucleic Acid Test Kit (eDiagnosis) and 2019-nCoV Nucleic Acid Diagnostic Kit (Sansure Biotech) are each made in China and maintain EUA by the Chinese CDC. Also, Sansure Biotech package has EUA by the FDA. In conclusion, our outcomes endorse the use of these two commercially out there kits imported to Ecuador for SARS-CoV-2 prognosis, as that they had the same scientific efficiency because the gold normal from the CDC.

With a globally ageing inhabitants, longevity is turning into essentially the most promising marketplace for the biotech trade. In animals, ageing may be retarded and longevity prolonged, which, if translated to people, would end result in large well being advantages with exceptional business worth. The potential to decelerate human ageing has led to a race to find essentially the most promising longevity medication in animals and in the end translate them to people. Indeed, in current years, there was exponential progress in longevity medication found in animal fashions. Investment in longevity biotech can be booming, and a number of scientific trials will quickly make clear which medication prolong wholesome lives. Thus, the longevity pharmacology subject guarantees to revolutionize the healthcare of a rising ageing inhabitants.

Neoadjuvant vascular-targeted photodynamic therapy improves survival and reduces recurrence and progression in a mouse model of urothelial cancer

Green recycling course of for polyurethane foams by a chem-biotech method

Polyurethanes are extremely resistant supplies used for constructing insulation or automotive seats. The polyurethane end-of-life concern have to be addressed by the event of environment friendly recycling methods. Since typical recycling processes aren’t appropriate for thermosets, waste administration of PU foam is especially questioning. By coupling organic and chemical processes, this examine goals at growing a inexperienced recycling pathway for PU foam utilizing enzymes for depolymerization. For occasion, enzymatic degradation of a PU foam synthesized with polycaprolactone and toluene diisocyanate led to a weight reduction of 25 % after 24 h of incubation.

GFP Lentivirus Control
MBS168880-5x1Vial	MyBiosource	5x1Vial	EUR 2650

GFP Control Lentivirus (Neo)
LV006	ABM	4 x 500 ul	EUR 195

GFP Control Lentivirus (Puro)
LV095	ABM	4 x 500 ul	EUR 195

RFP Lentivirus Control
LTV-301	Cell Biolabs	1 vial	EUR 679.2
Description: HIV-1 Lentivirus

EF1a control lentivirus (No Selection) EF1a control lentivirus (No Selection)
EF1a-Null-	GenTarget	1 x10^7 IFU/ml x 200ul	EUR 206.5
Description: Negative control lentivirus under EF1a promoter, does not contain any antibiotic selection.

CMV control lentivirus (Zeo)
CMV-Null-Zeo	GenTarget	1 x107 IFU/ml x 200ul	EUR 206.5
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

RFP Control Lentivirus (Neo)
LV058	ABM	4 x 500 ul	EUR 195

EF1a control lentivirus (Zeo)
EF1a-Null-Zeo	GenTarget	1 x107 IFU/ml x 200ul	EUR 206.5
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

RFP Control Lentivirus (Puro)
LV096	ABM	4 x 500 ul	EUR 195

CMV control lentivirus (Hygro)
CMV-Null-Hygro	GenTarget	1 x107 IFU/ml x 200ul	EUR 206.5
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

CAR negative control: CD28-CD3ζ (GFP-Puro) Lentivirus
CAR-ctr8	GenTarget	1x10^8 IFU/ml x 200ul	EUR 276.5
Description: CAR (CD28) control lentivirus without targeting domain, containing GFP-Puromycin dual selection

EF1a control lentivirus (Hygro)
EF1a-Null-Hygro	GenTarget	1 x107 IFU/ml x 200ul	EUR 206.5
Description: Negative control lentivirus contains a null spacer insert under EF1a promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

RFP (mRuby3) Control Lentivirus
LV101	ABM	4 x 500 ul	EUR 195

Scrambled shRNA Control Lentivirus
LSV-0024-1S	LipExoGen	2x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-2S	LipExoGen	2x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-3S	LipExoGen	2x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-4S	LipExoGen	2x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-5S	LipExoGen	2x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-6S	LipExoGen	2x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-7S	LipExoGen	2.5x10^6	EUR 395

Description: vsv-g

Scrambled shRNA Control Lentivirus
LSV-0024-8S	LipExoGen	2.5x10^6	EUR 395

Description: vsv-g

CAR negative control: 4-1BB-CD3ζ (GFP-Puro) Lentivirus
CAR-ctr7	GenTarget	1x10^8 IFU/ml x 200ul	EUR 276.5
Description: CAR (4-1BB) control lentivirus without targeting domain, containing GFP-Puromycin dual selection

RFP (TagRFP-T) Control Lentivirus
LV097	ABM	4 x 500 ul	EUR 195

Negative Control Luciferase Lentivirus
79578	BPS Bioscience	500 µl x 2	EUR 860
Description: The Negative Control Lentivirus (Firefly Luciferase) are replication incompetent, HIV-based, VSV-G pseudo typed lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene under the control of a minimal TATA promoter, without any additional transcriptional response elements.

CMV control lentivirus (No Selection)
CMV-Null-	GenTarget	1 x10^7 IFU/ml x 200ul	EUR 206.5
Description: Negative control lentivirus under CMV promoter, does not contain any antibiotic selection.

Expression Negative Control Lentivirus (G418)
79902-G	BPS Bioscience	500 µl x 2	EUR 795
Description: The Expression Negative Control Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The controls package the same virus particles as the target expression virus, but they do not express a specific protein under the CMV promoter. _x000D_The Expression Negative Control Lentivirus (G418) expresses the gene for aminoglycoside 3' phosphotransferase, which confers resistance to kanamycin, neomycin, and geneticin (G418)._x000D_The Expression Negative Control Lentivirus (Hygromycin) expresses the gene for hygromycin B phosphotransferase, which confers resistance to Hygromycin._x000D_The Expression Negative Control Lentivirus (Puromycin) expresses the gene for puromycin N-acetyl-transferase, which confers resistance to puromycin._x000D_ _x000D_

Expression Negative Control Lentivirus (Puromycin)
79902-P	BPS Bioscience	500 µl x 2	EUR 795
Description: The Expression Negative Control Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The controls package the same virus particles as the target expression virus, but they do not express a specific protein under the CMV promoter. _x000D_The Expression Negative Control Lentivirus (G418) expresses the gene for aminoglycoside 3' phosphotransferase, which confers resistance to kanamycin, neomycin, and geneticin (G418)._x000D_The Expression Negative Control Lentivirus (Hygromycin) expresses the gene for hygromycin B phosphotransferase, which confers resistance to Hygromycin._x000D_The Expression Negative Control Lentivirus (Puromycin) expresses the gene for puromycin N-acetyl-transferase, which confers resistance to puromycin._x000D_ _x000D_

Expression Negative Control Lentivirus (Hygromycin)
79902-H	BPS Bioscience	500 µl x 2	EUR 795
Description: The Expression Negative Control Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The controls package the same virus particles as the target expression virus, but they do not express a specific protein under the CMV promoter. _x000D_The Expression Negative Control Lentivirus (G418) expresses the gene for aminoglycoside 3' phosphotransferase, which confers resistance to kanamycin, neomycin, and geneticin (G418)._x000D_The Expression Negative Control Lentivirus (Hygromycin) expresses the gene for hygromycin B phosphotransferase, which confers resistance to Hygromycin._x000D_The Expression Negative Control Lentivirus (Puromycin) expresses the gene for puromycin N-acetyl-transferase, which confers resistance to puromycin._x000D_ _x000D_

CAR negative control: CD28-CD3ζ (No Select) Lentivirus
CAR-ctr6	GenTarget	1x10^8 IFU/ml x 200ul	EUR 276.5
Description: CAR (CD28) control lentivirus without targeting domain, does not contain any antibiotic selection

CMV Control (No Antibiotic), Concentrated Lentivirus in PBS
CMV-Null-PBS	GenTarget	1 x10^8 IFU/ml x 200ul	EUR 455
Description: Concentrated Negative control lentivirus under CMV promoter, contains no any antibioic selection.

EF1a Control (No Antibiotic), Concentrated Lentivirus in PBS
EF1a-Null-PBS	GenTarget	1 x10^8 IFU/ml x 200ul	EUR 455
Description: Concentrated Negative control lentivirus under EF1a promoter, contains no any antibioic selection.

CAR negative control: 4-1BB-CD3ζ (No Select) Lentivirus
CAR-ctr5	GenTarget	1x10^8 IFU/ml x 200ul	EUR 276.5
Description: CAR (4-1BB) control lentivirus without targeting domain, do not any antibiotic selection

AR-RFP (GFP) Lentivirus
LVP913-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the minimal promoter contains 4 tandem repeats of Androgen Response Element (ARE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AR-Luc (GFP) Lentivirus
LVP914-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the minimal promoter contains 4 tandem repeats of Androgen Response Element (ARE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-RFP (GFP) Lentivirus
LVP950-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-Luc (GFP) Lentivirus
LVP951-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-RFP (GFP) Lentivirus
LVP970-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-Luc (GFP) Lentivirus
LVP971-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-RFP (GFP) Lentivirus
LVP974-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-Luc (GFP) Lentivirus
LVP975-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

MB-RFP (GFP) Lentivirus
LVP1022-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human Myoglobin 's promoter which only expressed in muscle, predominantly in cardiac and skeletal myocytes. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

MB-Luc (GFP) Lentivirus
LVP1023-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human Myoglobin 's promoter which only expressed in muscle, predominantly in cardiac and skeletal myocytes. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AR-Rluc (GFP) Lentivirus
LVP915-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the minimal promoter contains 4 tandem repeats of Androgen Response Element (ARE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-RFP (GFP) Lentivirus
LVP946-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-Luc (GFP) Lentivirus
LVP947-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

G_RE-Rluc (GFP) Lentivirus
LVP952-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter embedded 4 tandem repeats of glucocorticoid response element (G-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-RFP (GFP) Lentivirus
LVP954-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-Luc (GFP) Lentivirus
LVP955-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-RFP (GFP) Lentivirus
LVP958-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-Luc (GFP) Lentivirus
LVP959-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-RFP (GFP) Lentivirus
LVP962-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-Luc (GFP) Lentivirus
LVP963-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

H_RE-Rluc (GFP) Lentivirus
LVP972-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 6 tandem repeats of hypoxia transcriptional response element (H-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ER-Rluc (GFP) Lentivirus
LVP976-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of estrogen receptor response element (ER-RE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-RFP (GFP) Lentivirus
LVP978-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-Luc (GFP) Lentivirus
LVP979-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-RFP (GFP) Lentivirus
LVP982-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-Luc (GFP) Lentivirus
LVP983-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

B29-RFP (GFP) Lentivirus
LVP994-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a human Immunoglobulin gene's promoter which demonstrates B-cell specific expression. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

B29-Luc (GFP) Lentivirus
LVP995-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a human Immunoglobulin gene's promoter which demonstrates B-cell specific expression. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

MB-Rluc (GFP) Lentivirus
LVP1024-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human Myoglobin 's promoter which only expressed in muscle, predominantly in cardiac and skeletal myocytes. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SPB-RFP (GFP) Lentivirus
LVP1026-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human Surfactant protein B's promoter which selectively expressed in bronchiolar and alveolar epithelial cells of the lung. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SPB-Luc (GFP) Lentivirus
LVP1027-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human Surfactant protein B's promoter which selectively expressed in bronchiolar and alveolar epithelial cells of the lung. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

aFP-RFP (GFP) Lentivirus
LVP1034-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human alpha-fetoprotein 's promoter which used for the expression into hepatocellular carcinoma cells . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

aFP-Luc (GFP) Lentivirus
LVP1035-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human alpha-fetoprotein 's promoter which used for the expression into hepatocellular carcinoma cells . This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

HE4-RFP (GFP) Lentivirus
LVP1042-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human HE4's promoter which is overexpressed in ovarian cancer cells. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

HE4-Luc (GFP) Lentivirus
LVP1043-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human HE4's promoter which is overexpressed in ovarian cancer cells. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

PSA-RFP (GFP) Lentivirus
LVP1046-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human PSA's promoter which expressed in normal prostate epithelium and prostate cancers. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

PSA-Luc (GFP) Lentivirus
LVP1047-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human PSA's promoter which expressed in normal prostate epithelium and prostate cancers. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ISRE-RFP (GFP) Lentivirus
LVP938-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter undera minimal promoter embeded 8 tandem repeats of ISRE (Interferon Stimulated Response Element). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ISRE-Luc (GFP) Lentivirus
LVP939-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter undera minimal promoter embeded 8 tandem repeats of ISRE (Interferon Stimulated Response Element). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-RFP (GFP) Lentivirus
LVP942-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-Luc (GFP) Lentivirus
LVP943-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Gli-Rluc (GFP) Lentivirus
LVP948-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter embeded 8 tandem repeats of Gli responsive element (hedgehog pathway). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

AP1-Rluc (GFP) Lentivirus
LVP956-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 8 tandem repeats of AP1 Responsive Element (AP1-RE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SRE-Rluc (GFP) Lentivirus
LVP960-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of serum response element (SRE) . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

RBP_JK-Rluc (GFP) Lentivirus
LVP964-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of RBP-JK transcriptional responsive element (RBP-JK TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-RFP (GFP) Lentivirus
LVP966-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-Luc (GFP) Lentivirus
LVP967-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

P53-Rluc (GFP) Lentivirus
LVP980-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded with optimized tandem repeats of a few most potent P53 transcriptional response element. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ARE-Rluc (GFP) Lentivirus
LVP984-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of antioxidant response element (ARE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-RFP (GFP) Lentivirus
LVP986-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-Luc (GFP) Lentivirus
LVP987-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

B29-Rluc (GFP) Lentivirus
LVP996-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a human Immunoglobulin gene's promoter which demonstrates B-cell specific expression. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD14-RFP (GFP) Lentivirus
LVP998-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the human CD14 promoter which demonstrates strongly upregulated expression during monocytic cell differentiation. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD14-Luc (GFP) Lentivirus
LVP999-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the human CD14 promoter which demonstrates strongly upregulated expression during monocytic cell differentiation. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD43-RFP (GFP) Lentivirus
LVP1002-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the human CD43 promoter which expressed on the surface of leukocytes and platelets.. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD43-Luc (GFP) Lentivirus
LVP1003-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the human CD43 promoter which expressed on the surface of leukocytes and platelets.. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD45-RFP (GFP) Lentivirus
LVP1006-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the human CD45's promoter which expressed exclusively by all hematopoietic cells except erythrocytes and platelets. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD45-Luc (GFP) Lentivirus
LVP1007-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the human CD45's promoter which expressed exclusively by all hematopoietic cells except erythrocytes and platelets. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD68-RFP (GFP) Lentivirus
LVP1010-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the human CD68's promoter which expressed specifically in macrophages and macrophage-related cells. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD68-Luc (GFP) Lentivirus
LVP1011-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the human CD68's promoter which expressed specifically in macrophages and macrophage-related cells. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Flt1-RFP (GFP) Lentivirus
LVP1014-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the human Flt-1's promoter which expressed specifically in endothelial cells and up-regulated in tumor vasculature. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Flt1-Luc (GFP) Lentivirus
LVP1015-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the human Flt-1's promoter which expressed specifically in endothelial cells and up-regulated in tumor vasculature. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SPB-Rluc (GFP) Lentivirus
LVP1028-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human Surfactant protein B's promoter which selectively expressed in bronchiolar and alveolar epithelial cells of the lung. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SYN1-RFP (GFP) Lentivirus
LVP1030-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human Synapsin 's promoter which used for neuron-specific high expression. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SYN1-Luc (GFP) Lentivirus
LVP1031-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human Synapsin 's promoter which used for neuron-specific high expression. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

aFP-Rluc (GFP) Lentivirus
LVP1036-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human alpha-fetoprotein 's promoter which used for the expression into hepatocellular carcinoma cells . This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

HE4-Rluc (GFP) Lentivirus
LVP1044-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human HE4's promoter which is overexpressed in ovarian cancer cells. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

PSA-Rluc (GFP) Lentivirus
LVP1048-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human PSA's promoter which expressed in normal prostate epithelium and prostate cancers. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

EGR1-RFP (GFP) Lentivirus
LVP1120-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the promoter of human early growth response gene-1 (EGR1). This lentivirus contains another fluorescent marker GFP under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

EGR1-RFP (GFP) Lentivirus
LVP1120-G-PBS	GenTarget	1x108 IFU/ml x 200ul	EUR 455
Description: Pre-made lentivirus express RFP reporter under the promoter of human early growth response gene-1 (EGR1). This lentivirus contains another fluorescent marker GFP under RSV promoter, provided in PBS solution.

EGR1-Luc (GFP) Lentivirus
LVP1121-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly Luciferase reporter under the promoter of human early growth response gene-1 (EGR1). This lentivirus contains the fluorescent marker GFP under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

EGR1-Luc (GFP) Lentivirus
LVP1121-G-PBS	GenTarget	1x108 IFU/ml x 200ul	EUR 455
Description: Pre-made lentivirus express Firefly Luciferase reporter under the promoter of human early growth response gene-1 (EGR1). This lentivirus contains the fluorescent marker GFP under RSV promoter, provided in PBS solution.

GFAP-RFP (GFP) Lentivirus
LVP1126-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human GFAP's promoter which expressed in astrocytes in Central Nervous System. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

GFAP-RFP (GFP) Lentivirus
LVP1126-G-PBS	GenTarget	1x108 IFU/ml x 200ul	EUR 455
Description: Pre-made lentivirus express RFP reporter under human GFAP's promoter which expressed in astrocytes in Central Nervous System. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter. Lentivirus concentrated and provided in PBS solution.

GFAP-Luc (GFP) Lentivirus
LVP1127-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human GFAP's promoter which expressed in astrocytes in Central Nervous System. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

GFAP-Luc (GFP) Lentivirus
LVP1127-G-PBS	GenTarget	1x108 IFU/ml x 200ul	EUR 455
Description: Pre-made lentivirus express Firefly luciferase reporter under human GFAP's promoter which expressed in astrocytes in Central Nervous System. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter. Lentivirus concentrated and provided in PBS solution.

ISRE-Rluc (GFP) Lentivirus
LVP940-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter undera minimal promoter embeded 8 tandem repeats of ISRE (Interferon Stimulated Response Element). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CRE_TRE-Rluc (GFP) Lentivirus
LVP944-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter embeded 8 tandem repeats of cAMP response motif (CRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

NFkB-Rluc (GFP) Lentivirus
LVP968-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 4 tandem repeats of NFκB transcriptional response element (NFkB-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CEBP-Rluc (GFP) Lentivirus
LVP988-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under a minimal promoter that embedded 8 tandem repeats of C/EBP transcriptional response element (C/EBP-TRE). This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

GATA2-RFP (GFP) Lentivirus
LVP990-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under GATA-2 promoter which dynamically expressed in hematopoietic tissues and in the central nervous system. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

GATA2-Luc (GFP) Lentivirus
LVP991-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under GATA-2 promoter which dynamically expressed in hematopoietic tissues and in the central nervous system. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD14-Rluc (GFP) Lentivirus
LVP1000-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the human CD14 promoter, carrying GFP reporter

CD43-Rluc (GFP) Lentivirus
LVP1004-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the human CD43 promoter which expressed on the surface of leukocytes and platelets.. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD45-Rluc (GFP) Lentivirus
LVP1008-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the human CD45's promoter which expressed exclusively by all hematopoietic cells except erythrocytes and platelets. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CD68-Rluc (GFP) Lentivirus
LVP1012-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the human CD68's promoter which expressed specifically in macrophages and macrophage-related cells. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

Flt1-Rluc (GFP) Lentivirus
LVP1016-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the human Flt-1's promoter which expressed specifically in endothelial cells and up-regulated in tumor vasculature. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ICAM2-RFP (GFP) Lentivirus
LVP1018-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under the human ICAM-2's promoter which expressed specifically in vasculature endothelial cells and megakaryocytes. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ICAM2-Luc (GFP) Lentivirus
LVP1019-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under the human ICAM-2's promoter which expressed specifically in vasculature endothelial cells and megakaryocytes. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

SYN1-Rluc (GFP) Lentivirus
LVP1032-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human Synapsin 's promoter which used for neuron-specific high expression. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CCKAR-RFP (GFP) Lentivirus
LVP1038-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human CCKR's promoter which is predominantly expressed in human pancreatic cancer. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CCKAR-Luc (GFP) Lentivirus
LVP1039-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Firefly luciferase reporter under human CCKR's promoter which is predominantly expressed in human pancreatic cancer. This lentivirus also contain the GFP selection marker under the consitutiveRSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

EGR1-Rluc (GFP) Lentivirus
LVP1122-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla Luciferase reporter under the promoter of human early growth response gene-1 (EGR1). This lentivirus contains the fluorescent marker GFP under RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

EGR1-Rluc (GFP) Lentivirus
LVP1122-G-PBS	GenTarget	1x108 IFU/ml x 200ul	EUR 455
Description: Pre-made lentivirus express Renilla Luciferase reporter under the promoter of human early growth response gene-1 (EGR1). This lentivirus contains the fluorescent marker GFP under RSV promoter, provided in PBS solution.

GFAP-Rluc (GFP) Lentivirus
LVP1128-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human GFAP's promoter which expressed in astrocytes in Central Nervous System. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

GFAP-Rluc (GFP) Lentivirus
LVP1128-G-PBS	GenTarget	1x108 IFU/ml x 200ul	EUR 455
Description: Pre-made lentivirus express Renilla luciferase reporter under human GFAP's promoter which expressed in astrocytes in Central Nervous System. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter. Lentivirus concentrated and provided in PBS solution.

CMV Promoter GFP Lentivirus
G373	ABM	200 μl, Titer: 1x10^7 IU/ml	EUR 475
Description: N/A

UbC Promoter GFP Lentivirus
G383	ABM	200 μl, Titer: 1x10^7 IU/ml	EUR 475
Description: N/A

PGK Promoter GFP Lentivirus
G384	ABM	200 μl, Titer: 1x10^7 IU/ml	EUR 475
Description: N/A

GATA2-Rluc (GFP) Lentivirus
LVP992-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under GATA-2 promoter which dynamically expressed in hematopoietic tissues and in the central nervous system. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

ICAM2-Rluc (GFP) Lentivirus
LVP1020-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under the human ICAM-2's promoter which expressed specifically in vasculature endothelial cells and megakaryocytes. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CCKAR-Rluc (GFP) Lentivirus
LVP1040-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express Renilla luciferase reporter under human CCKR's promoter which is predominantly expressed in human pancreatic cancer. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

CamKII-RFP (GFP) Lentivirus
LVP1054-G	GenTarget	1x107 IFU/ml x 200ul	EUR 346.5
Description: Pre-made lentivirus express RFP reporter under human CamKII's promoter which restrictly expressed in neurons of the neocortex and hippocampus, also pyramidal neurons. This lentivirus also contain the GFP selection marker under the consitutive RSV promoter, provided in DMEM medium with 10% FBS and 60ug/ml of polybrene.

The corresponding degradation merchandise have been recovered and recognized as 6-hydroxycaproic acid and a quick acid-terminated diurethane. An organo-metallic catalyzed synthesis of second technology polymers from these constructing blocks was carried out. A polymer with a excessive common molar mass of 74 000 (Mw) was obtained by mixing 50 % of recycled constructing blocks and 50 % of neat 6-hydroxycaproic acid. A poly(ester urethane) have been synthesized with out the use of poisonous and decrier polyisocyanates. It is the primary time that a examine provides the imaginative and prescient of a recycling loop ranging from PU wastes and ending with a second technology polymer in a full round method.

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

Posted on April 1, 2021 by Pat Lynch blocking peptide blood cDNA ChiP coli recombinant colorimetric Control Cultrex Default Dot EIA electrophoresis First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Goat Rabbit Species The New Paradigms in Clinical Research: From Early Access Programs to the Novel Therapeutic Approaches for Unmet Medical Needs. What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

ConspectusAntimicrobial resistance to present antibiotics represents one of many best threats to human well being and is rising at an alarming price. To additional complicate therapy of bacterial infections, many power infections are the results of bacterial biofilms which are tolerant to therapy with antibiotics due to the presence of metabolically dormant persister cell populations. Together these threats are creating an rising burden on the healthcare system, and a “preantibiotic” age is on the horizon if vital motion will not be taken by the scientific and medical communities. While the golden period of antibiotic discovery (1940s-1960s) produced a lot of the antibiotic courses in scientific use at this time, adopted by a number of many years of restricted growth, there was a resurgence in antibiotic drug discovery lately fueled by the tutorial and biotech sectors.

Historically, nice success has been achieved by growing next-generation variants of present courses of antibiotics, however there stays a dire want for the identification of novel scaffolds and/or antimicrobial targets to drive future efforts to overcome resistance and tolerance. In this regard, there was no extra priceless supply for the identification of antibiotics than pure merchandise, with 69-77% of accepted antibiotics both being such compounds or being derived from them.Our group has developed a program centered on the chemical synthesis and chemical microbiology of marine pure merchandise with uncommon buildings and promising ranges of exercise towards multidrug-resistant (MDR) bacterial pathogens.

As we’re motivated by making ready and finding out the organic results of those molecules, we aren’t initially pursuing a organic query however as an alternative are permitting the noticed phenotypes and actions to information the last word challenge path. In this Account, our latest efforts on the synoxazolidinone, lipoxazolidinone, and batzelladine pure merchandise might be mentioned and positioned within the context of the sphere’s best challenges and alternatives. Specifically, the synoxazolidinone household of 4-oxazolidinone-containing pure merchandise has led to the event of a number of chemical strategies to put together antimicrobial scaffolds and has revealed compounds with potent exercise as adjuvants to deal with bacterial biofilms. Bearing the identical 4-oxazolidinone core, the lipoxazolidinones have confirmed to be potent single-agent antibiotics.

Finally, our artificial efforts towards the batzelladines revealed analogues with exercise towards a variety of MDR pathogens, highlighted by non-natural stereochemical isomers with superior exercise and simplified artificial entry. Taken collectively, these research present a number of distinct platforms for the event of novel therapeutics that may add to our arsenal of scaffolds for preclinical growth and can present perception into the biochemical processes and pathways that may be focused by small molecules within the battle towards antimicrobial-resistant and -tolerant infections. We hope that this work will serve as inspiration for elevated efforts by the scientific neighborhood to leverage artificial chemistry and chemical microbiology towards novel antibiotics that may fight the rising disaster of MDR and tolerant bacterial infections.

Life sciences mental property licensing on the Massachusetts Institute of Technology

Academic establishments play a central position within the biotech trade by means of know-how licensing and the creation of startups, however few information can be found on their efficiency and the magnitude of their affect. Here we current a systematic research of know-how licensing by one such establishment, the Massachusetts Institute of Technology (MIT). Using information on the 76 therapeutics-focused life sciences corporations shaped by means of MIT’s Technology Licensing Office from 1983 to 2017, we assemble a number of measures of affect, together with MIT patents cited within the Orange Book

capital raised, outcomes from mergers and acquisitions, patents granted to MIT mental property licensees, drug candidates found and US drug approvals-a key benchmark of innovation within the biopharmaceutical trade. As of December 2017, Orange Book listings for 4 accepted small-molecule medicine cite MIT patents, however one other 31 FDA-approved medicine (excluding candidates acquired after section 3) had some involvement of MIT licensees. Fifty-five % of the latter had been both a new molecular entity or a new organic entity, and 55% had been granted precedence evaluate, a sign that they handle an unmet medical want.

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

Recent Advances within the Evaluation of Serological Assays for the Diagnosis of SARS-CoV-2 Infection and COVID-19

Few information on the diagnostic efficiency of serological exams for extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) an infection are presently out there. We evaluated sensitivity and specificity of 5 completely different extensively used industrial serological assays for the detection of SARS-CoV-2-specific IgG, IgM, and IgA antibodies utilizing reverse transcriptase-PCR assay in nasopharyngeal swab as reference customary take a look at. The methodology described right here could also be a helpful framework for different educational establishments to monitor outcomes of mental property within the therapeutics area

A complete of 337 plasma samples collected within the interval April-June 2020 from SARS-CoV-2 RT-PCR optimistic (n = 207) and destructive (n = 130) topics had been investigated by one point-of-care lateral stream immunochromatographic assay (LFIA IgG and IgM, Technogenetics) and 4 totally automated assays: two chemiluminescence immunoassays (CLIA-iFlash IgG and IgM, Shenzhen YHLO Biotech and CLIA-LIAISON XL IgG, DiaSorin), one electrochemiluminescence immunoassay (ECLIA-Elecsys^® whole predominant IgG, Roche), and one enzyme-linked immunosorbent assay (ELISA IgA, Euroimmune.

Mouse IgG2a Isotype Control
abx139004-01mg	Abbexa	0.1 mg	EUR 376.8

Mouse IgG2a Isotype Control
abx139004-100l	Abbexa	100 µl	EUR 250

Mouse IgG2a Isotype Control
abx139004-500l	Abbexa	500 µl	Ask for price

Mouse IgG2a Isotype Control
abx139005-01mg	Abbexa	0.1 mg	EUR 376.8

Mouse IgG2a Isotype Control
abx139005-100l	Abbexa	100 µl	EUR 250

Mouse IgG2a Isotype Control
abx139005-500l	Abbexa	500 µl	Ask for price

Mouse IgG2a Isotype Control
abx139009-01mg	Abbexa	0.1 mg	EUR 376.8

Mouse IgG2a Isotype Control
abx139009-100l	Abbexa	100 µl	EUR 250

Mouse IgG2a Isotype Control
abx139009-500l	Abbexa	500 µl	Ask for price

Mouse IgG2a Isotype Control
abx405013-100tests	Abbexa	100 tests	EUR 493.2

Mouse IgG2a Isotype Control
abx405013-250g	Abbexa	250 µg	EUR 300

Mouse IgG2a Isotype Control
abx405015-05mg	Abbexa	0.5 mg	EUR 828

Mouse IgG2a Isotype Control
abx405018-100g	Abbexa	100 µg	EUR 975

Mouse IgG2a Isotype Control
abx405018-1mg	Abbexa	1 mg	EUR 1328.4

Mouse IgG2a Isotype Control
abx405070-100g	Abbexa	100 µg	EUR 300

Mouse IgG2a Isotype Control
abx405070-100tests	Abbexa	100 tests	EUR 493.2

Mouse IgG2a Isotype Control
abx405073-05mg	Abbexa	0.5 mg	EUR 994.8

Mouse IgG2a Isotype Control
abx405073-250g	Abbexa	250 µg	EUR 712.5

Mouse IgG2a Isotype Control
abx200572-100ug	Abbexa	100 ug	EUR 376.8

Mouse IgG2a Isotype Control
MBS136147-1mg	MyBiosource	1mg	EUR 465

Mouse IgG2a Isotype Control
MBS136147-5mg	MyBiosource	5mg	EUR 1540

Mouse IgG2a Isotype Control
MBS136147-5x5mg	MyBiosource	5x5mg	EUR 6695

Mouse IgG2a Isotype Control
ICIGG2AA-50	ImmunoStep	50 µg	EUR 231

Mouse IgG2a Isotype Control
ICIGG2AF-100	ImmunoStep	100 µg	EUR 126.5

Mouse IgG2a Isotype Control
ICIGG2APE-50	ImmunoStep	50 µg	EUR 231

Mouse IgG2a Isotype Control
ICIGG2APP-100	ImmunoStep	100 µg	EUR 253

Mouse IgG2a Isotype Control
ICIGG2APP5.5-100	ImmunoStep	100 µg	EUR 253

Mouse IgG2a Isotype Control
ICIGG2APU-100	ImmunoStep	100 µg	EUR 126.5

Mouse IgG2a Isotype Control
GWB-957238	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-A0AD5F	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-AEF91A	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-B53172	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-FA4739	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-C47D63	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-727CA0	GenWay Biotech	0.5 mg	Ask for price

Mouse IgG2a Isotype Control
GWB-7829DA	GenWay Biotech	1 mg	Ask for price

Mouse IgG2a Isotype Control
GWB-260585	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-1C9451	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-21CA6B	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-233A6A	GenWay Biotech	100 TESTS	Ask for price

Mouse IgG2a Isotype Control
GWB-148AA9	GenWay Biotech	0.5 mg	Ask for price

Mouse IgG2a Isotype Control
E2790004	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control
MBS378376-05mg	MyBiosource	0.5mg	EUR 410

Mouse IgG2a Isotype Control
MBS378376-5x05mg	MyBiosource	5x0.5mg	EUR 1550

Mouse IgG2a Isotype Control
MBS4753518-01mL	MyBiosource	0.1mL	EUR 450

Mouse IgG2a Isotype Control
MBS4753518-5x01mL	MyBiosource	5x0.1mL	EUR 1540

Mouse IgG2a Isotype Control
MBS531354-1mg	MyBiosource	1mg	EUR 690

Mouse IgG2a Isotype Control
MBS531354-5x1mg	MyBiosource	5x1mg	EUR 2945

Mouse IgG2a Isotype Control
MBS655548-005mg	MyBiosource	0.05mg	EUR 475

Mouse IgG2a Isotype Control
MBS655548-5x005mg	MyBiosource	5x0.05mg	EUR 1990

Mouse IgG2a Isotype Control
MBS8559155-01mL	MyBiosource	0.1mL	EUR 305

Mouse IgG2a Isotype Control
MBS8559155-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Mouse IgG2a Isotype Control
MBS8559155-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Mouse IgG2a Isotype Control
MBS8559155-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Mouse IgG2a Isotype Control
MBS8559155-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Mouse IgG2a Isotype Control PE
1P-724-C025	ExBio	0.025 mg	EUR 99

Mouse IgG2a Isotype Control PE
1P-724-C100	ExBio	0.1 mg	EUR 198

Mouse IgG2a Isotype Control (PE)
abx139015-01mg	Abbexa	0.1 mg	EUR 510

Mouse IgG2a Isotype Control (PE)
abx139015-100l	Abbexa	100 µl	EUR 350

Mouse IgG2a Isotype Control (PE)
abx139015-500l	Abbexa	500 µl	Ask for price

Mouse IgG2a Isotype Control (PE)
abx405017-100g	Abbexa	100 µg	EUR 512.5

Mouse IgG2a Isotype Control (PE)
abx405075-100g	Abbexa	100 µg	Ask for price

Mouse IgG2a Isotype Control (PE)
abx405075-250g	Abbexa	250 µg	Ask for price

Mouse IgG2a Isotype Control (PE)
abx405075-25g	Abbexa	25 µg	EUR 362.5

Mouse IgG2a Isotype Control (PE)
abx200574-50ug	Abbexa	50 ug	EUR 510

Mouse IgG2a Isotype Control (PE)
abx159557-100g	Abbexa	100 µg	Ask for price

Mouse IgG2a Isotype Control (PE)
abx159557-10g	Abbexa	10 µg	EUR 325

Mouse IgG2a Isotype Control (PE)
abx159557-50g	Abbexa	50 µg	Ask for price

PE mouse IgG2a Isotype Control
E16FMCP002-050	EnoGene	50 tests	EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG2a Isotype Control
E16FMCP002-100	EnoGene	100 Tests	EUR 336
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control (PE)
E2790239	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control PE
MBS1801354-01mg	MyBiosource	0.1mg	EUR 305

Mouse IgG2a Isotype Control PE
MBS1801354-5x01mg	MyBiosource	5x0.1mg	EUR 1120

Mouse IgG2a Isotype Control (PE)
MBS4753794-01mL	MyBiosource	0.1mL	EUR 450

Mouse IgG2a Isotype Control (PE)
MBS4753794-5x01mL	MyBiosource	5x0.1mL	EUR 1540

Mouse IgG2a Isotype Control PE
MBS697144-01mg	MyBiosource	0.1mg	EUR 225

Mouse IgG2a Isotype Control PE
MBS697144-5x01mg	MyBiosource	5x0.1mg	EUR 965

Mouse IgG2a Isotype Control (PE)
MBS8576112-01mL	MyBiosource	0.1mL	EUR 305

Mouse IgG2a Isotype Control (PE)
MBS8576112-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Mouse IgG2a Isotype Control (PE)
MBS8576112-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Mouse IgG2a Isotype Control (PE)
MBS8576112-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Mouse IgG2a Isotype Control (PE)
MBS8576112-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

Mouse IgG2a Isotype Control APC
1A-724-C025	ExBio	0.025 mg	EUR 99

Mouse IgG2a Isotype Control APC
1A-724-C100	ExBio	0.1 mg	EUR 198

Mouse IgG2a Isotype Control (APC)
abx139012-01mg	Abbexa	0.1 mg	EUR 510

Mouse IgG2a Isotype Control (APC)
abx139012-100l	Abbexa	100 µl	EUR 350

Mouse IgG2a Isotype Control (APC)
abx139012-500l	Abbexa	500 µl	Ask for price

Mouse IgG2a Isotype Control (RPE)
abx405017-100tests	Abbexa	100 tests	EUR 760.8

Mouse IgG2a Isotype Control (APC)
abx405071-100g	Abbexa	100 µg	EUR 325

Mouse IgG2a Isotype Control (APC)
abx405071-100tests	Abbexa	100 tests	EUR 510

Mouse IgG2a Isotype Control (RPE)
abx405075-100tests	Abbexa	100 tests	EUR 560.4

Mouse IgG2a Isotype Control (APC)
abx200575-50ug	Abbexa	50 ug	EUR 510

APC mouse IgG2a Isotype Control
E16FMCA002-050	EnoGene	50 tests	EUR 268.8
Description: Available in various conjugation types.

APC mouse IgG2a Isotype Control
E16FMCA002-100	EnoGene	100 Tests	EUR 403.2
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control (APC)
E2790222	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control APC
MBS1801351-01mg	MyBiosource	0.1mg	EUR 305

Mouse IgG2a Isotype Control APC
MBS1801351-5x01mg	MyBiosource	5x0.1mg	EUR 1120

Mouse IgG2a Isotype Control (APC)
MBS4753778-01mL	MyBiosource	0.1mL	EUR 450

Mouse IgG2a Isotype Control (APC)
MBS4753778-5x01mL	MyBiosource	5x0.1mL	EUR 1540

Mouse IgG2a Isotype Control APC
MBS697147-01mg	MyBiosource	0.1mg	EUR 235

Mouse IgG2a Isotype Control APC
MBS697147-5x01mg	MyBiosource	5x0.1mg	EUR 1025

Mouse IgG2a Isotype Control (APC)
MBS8576095-01mL	MyBiosource	0.1mL	EUR 305

Mouse IgG2a Isotype Control (APC)
MBS8576095-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Mouse IgG2a Isotype Control (APC)
MBS8576095-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Mouse IgG2a Isotype Control (APC)
MBS8576095-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Mouse IgG2a Isotype Control (APC)
MBS8576095-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

APC mouse IgG2a Isotype Control
MBS9459473-100Tests	MyBiosource	100Tests	EUR 290

APC mouse IgG2a Isotype Control
MBS9459473-50Tests	MyBiosource	50Tests	EUR 230

APC mouse IgG2a Isotype Control
MBS9459473-5x100Tests	MyBiosource	5x100Tests	EUR 1160

Mouse IgG2a Isotype Control, APC
MBS8500905-100Tests	MyBiosource	100Tests	EUR 305

Mouse IgG2a Isotype Control, APC
MBS8500905-50Tests	MyBiosource	50Tests	EUR 235

Mouse IgG2a Isotype Control, APC
MBS8500905-5x100Tests	MyBiosource	5x100Tests	EUR 1220

Mouse IgG2a Isotype Control FITC
1F-724-C025	ExBio	0.025 mg	EUR 82.5

Mouse IgG2a Isotype Control FITC
1F-724-C100	ExBio	0.1 mg	EUR 165

Mouse IgG2a Isotype Control (FITC)
abx139014-01mg	Abbexa	0.1 mg	EUR 460.8

Mouse IgG2a Isotype Control (FITC)
abx139014-100l	Abbexa	100 µl	EUR 300

Mouse IgG2a Isotype Control (FITC)
abx139014-500l	Abbexa	500 µl	Ask for price

Mouse IgG2a Isotype Control (FITC)
abx405016-01mg	Abbexa	0.1 mg	EUR 610.8

Mouse IgG2a Isotype Control (FITC)
abx405016-100g	Abbexa	100 µg	EUR 400

Mouse IgG2a Isotype Control (FITC)
abx405074-100g	Abbexa	100 µg	EUR 300

Mouse IgG2a Isotype Control (FITC)
abx405074-100tests	Abbexa	100 tests	EUR 493.2

Mouse IgG2a Isotype Control (FITC)
abx200573-100ug	Abbexa	100 ug	EUR 376.8

Mouse IgG2a Isotype Control (FITC)
abx159556-100g	Abbexa	100 µg	Ask for price

The general sensitivity of all IgG serological assays was >80% and the specificity was >97%. The sensitivity of IgG assays was decrease inside 2 weeks from the onset of signs starting from 70.8 to 80%. The LFIA and CLIA-iFlash IgM confirmed an general low sensitivity of 47.6 and 54.6%, whereas the specificity was 98.5 and 96.2%, respectively. The ELISA IgA yielded a sensitivity of 84.3% and specificity of 81.7%. However, the ELISA IgA consequence was indeterminate in 11.7% of circumstances.